Disruption of TLR3 Signaling Due to Cleavage of TRIF by the Hepatitis A Virus Protease-Polymerase Processing Intermediate, 3CD

Lin Qu; Zongdi Feng; Daisuke Yamane; Yuqiong Liang; Robert E. Lanford; Kui Li; Stanley M. Lemon

doi:10.1371/journal.ppat.1002169

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Peer-reviewed

Research Article

Disruption of TLR3 Signaling Due to Cleavage of TRIF by the Hepatitis A Virus Protease-Polymerase Processing Intermediate, 3CD

Lin Qu ,

* E-mail: smlemon@med.unc.edu

Current address: Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America.

Affiliation Lineberger Comprehensive Cancer Center and the Division of Infectious Diseases, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
⨯
Zongdi Feng,

Affiliation Lineberger Comprehensive Cancer Center and the Division of Infectious Diseases, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
⨯
Daisuke Yamane,

Affiliation Lineberger Comprehensive Cancer Center and the Division of Infectious Diseases, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
⨯
Yuqiong Liang,

Affiliation Lineberger Comprehensive Cancer Center and the Division of Infectious Diseases, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
⨯
Robert E. Lanford,

Affiliation Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, Texas, United States of America
⨯
Kui Li,

Affiliation Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
⨯
Stanley M. Lemon

Affiliation Lineberger Comprehensive Cancer Center and the Division of Infectious Diseases, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
⨯

Disruption of TLR3 Signaling Due to Cleavage of TRIF by the Hepatitis A Virus Protease-Polymerase Processing Intermediate, 3CD

Lin Qu,
Zongdi Feng,
Daisuke Yamane,
Yuqiong Liang,
Robert E. Lanford,
Kui Li,
Stanley M. Lemon

Published: September 8, 2011
https://doi.org/10.1371/journal.ppat.1002169

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Immune receptor signaling
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Hepatitis A virus
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Proteases
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Hepatitis C virus
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Immunoblotting
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Signal processing
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Viral replication
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Transfection
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