The Role of IL-15 Deficiency in the Pathogenesis of Virus-Induced Asthma Exacerbations

Vasile Laza-Stanca; Simon D. Message; Michael R. Edwards; Hayley L. Parker; Mihnea T. Zdrenghea; Tatiana Kebadze; Onn M. Kon; Patrick Mallia; Luminita A. Stanciu; Sebastian L. Johnston

doi:10.1371/journal.ppat.1002114

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Open Access

Peer-reviewed

Research Article

The Role of IL-15 Deficiency in the Pathogenesis of Virus-Induced Asthma Exacerbations

Vasile Laza-Stanca,

Affiliation Department of Respiratory Medicine, National Heart and Lung Institute, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, Centre for Respiratory Infection, Imperial College London, London, United Kingdom
⨯
Simon D. Message,

Affiliations Department of Respiratory Medicine, National Heart and Lung Institute, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, Centre for Respiratory Infection, Imperial College London, London, United Kingdom, Imperial College Healthcare NHS Trust, London, United Kingdom
⨯
Michael R. Edwards,

Affiliation Department of Respiratory Medicine, National Heart and Lung Institute, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, Centre for Respiratory Infection, Imperial College London, London, United Kingdom
⨯
Hayley L. Parker,

Affiliation Department of Respiratory Medicine, National Heart and Lung Institute, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, Centre for Respiratory Infection, Imperial College London, London, United Kingdom
⨯
Mihnea T. Zdrenghea,

Affiliation Department of Respiratory Medicine, National Heart and Lung Institute, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, Centre for Respiratory Infection, Imperial College London, London, United Kingdom
⨯
Tatiana Kebadze,

Affiliation Department of Respiratory Medicine, National Heart and Lung Institute, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, Centre for Respiratory Infection, Imperial College London, London, United Kingdom
⨯
Onn M. Kon,

Affiliation Imperial College Healthcare NHS Trust, London, United Kingdom
⨯
Patrick Mallia,

Affiliations Department of Respiratory Medicine, National Heart and Lung Institute, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, Centre for Respiratory Infection, Imperial College London, London, United Kingdom, Imperial College Healthcare NHS Trust, London, United Kingdom
⨯
Luminita A. Stanciu ,

Contributed equally to this work with: Luminita A. Stanciu, Sebastian L. Johnston

* E-mail: l.stanciu@imperial.ac.uk

Affiliation Department of Respiratory Medicine, National Heart and Lung Institute, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, Centre for Respiratory Infection, Imperial College London, London, United Kingdom
⨯
Sebastian L. Johnston

Contributed equally to this work with: Luminita A. Stanciu, Sebastian L. Johnston

Affiliations Department of Respiratory Medicine, National Heart and Lung Institute, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, Centre for Respiratory Infection, Imperial College London, London, United Kingdom, Imperial College Healthcare NHS Trust, London, United Kingdom
⨯

The Role of IL-15 Deficiency in the Pathogenesis of Virus-Induced Asthma Exacerbations

Vasile Laza-Stanca,
Simon D. Message,
Michael R. Edwards,
Hayley L. Parker,
Mihnea T. Zdrenghea,
Tatiana Kebadze,
Onn M. Kon,
Patrick Mallia,
Luminita A. Stanciu,
Sebastian L. Johnston

Published: July 14, 2011
https://doi.org/10.1371/journal.ppat.1002114

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Asthma
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Macrophages
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Rhinovirus infection
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Immune deficiency
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Alveolar macrophages
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