Stromal Down-Regulation of Macrophage CD4/CCR5 Expression and NF-κB Activation Mediates HIV-1 Non-Permissiveness in Intestinal Macrophages

Ruizhong Shen; Gang Meng; Christina Ochsenbauer; Paul R. Clapham; Jayleen Grams; Lea Novak; John C. Kappes; Lesley E. Smythies; Phillip D. Smith

doi:10.1371/journal.ppat.1002060

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Peer-reviewed

Research Article

Stromal Down-Regulation of Macrophage CD4/CCR5 Expression and NF-κB Activation Mediates HIV-1 Non-Permissiveness in Intestinal Macrophages

Ruizhong Shen,

Affiliation Department of Medicine (Gastroenterology), University of Alabama at Birmingham, Birmingham, Alabama, United Sates of America
⨯
Gang Meng,

Affiliation Lutheran Family Health Centers, Brooklyn, New York, United States of America
⨯
Christina Ochsenbauer,

Affiliation Department of Medicine (Hematology/Oncology), University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Paul R. Clapham,

Affiliation Program in Molecular Medicine and Microbiology, University of Massachusetts, Worcester, Massachusetts, United States of America
⨯
Jayleen Grams,

Affiliation Department of Surgery (Gastrointestinal), University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Lea Novak,

Affiliation Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
John C. Kappes,

Affiliations Department of Medicine (Hematology/Oncology), University of Alabama at Birmingham, Birmingham, Alabama, United States of America, VA Medical Center, Birmingham, Alabama, United States of America
⨯
Lesley E. Smythies,

Affiliation Department of Medicine (Gastroenterology), University of Alabama at Birmingham, Birmingham, Alabama, United Sates of America
⨯
Phillip D. Smith

* E-mail: pdsmith@uab.edu

Affiliations Department of Medicine (Gastroenterology), University of Alabama at Birmingham, Birmingham, Alabama, United Sates of America, VA Medical Center, Birmingham, Alabama, United States of America
⨯

Stromal Down-Regulation of Macrophage CD4/CCR5 Expression and NF-κB Activation Mediates HIV-1 Non-Permissiveness in Intestinal Macrophages

Ruizhong Shen,
Gang Meng,
Christina Ochsenbauer,
Paul R. Clapham,
Jayleen Grams,
Lea Novak,
John C. Kappes,
Lesley E. Smythies,
Phillip D. Smith

Published: May 26, 2011
https://doi.org/10.1371/journal.ppat.1002060

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