Viral CTL Escape Mutants Are Generated in Lymph Nodes and Subsequently Become Fixed in Plasma and Rectal Mucosa during Acute SIV Infection of Macaques

Thomas H. Vanderford; Chelsea Bleckwehl; Jessica C. Engram; Richard M. Dunham; Nichole R. Klatt; Mark B. Feinberg; David A. Garber; Michael R. Betts; Guido Silvestri

doi:10.1371/journal.ppat.1002048

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Peer-reviewed

Research Article

Viral CTL Escape Mutants Are Generated in Lymph Nodes and Subsequently Become Fixed in Plasma and Rectal Mucosa during Acute SIV Infection of Macaques

Thomas H. Vanderford,

Affiliations Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Chelsea Bleckwehl,

Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Jessica C. Engram,

Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Richard M. Dunham,

Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Nichole R. Klatt,

Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Mark B. Feinberg,

Affiliation Merck Vaccines and Infectious Diseases, Merck and Co., Inc., West Point, Pennsylvania, United States of America
⨯
David A. Garber,

Affiliation Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America
⨯
Michael R. Betts,

Affiliation Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Guido Silvestri

* E-mail: gsilves@emory.edu

Affiliations Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯

Viral CTL Escape Mutants Are Generated in Lymph Nodes and Subsequently Become Fixed in Plasma and Rectal Mucosa during Acute SIV Infection of Macaques

Thomas H. Vanderford,
Chelsea Bleckwehl,
Jessica C. Engram,
Richard M. Dunham,
Nichole R. Klatt,
Mark B. Feinberg,
David A. Garber,
Michael R. Betts,
Guido Silvestri

Published: May 19, 2011
https://doi.org/10.1371/journal.ppat.1002048

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SIV
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Lymph nodes
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