Transcriptome Analysis of Neisseria meningitidis in Human Whole Blood and Mutagenesis Studies Identify Virulence Factors Involved in Blood Survival

Open Access

Peer-reviewed

Research Article

Hebert Echenique-Rivera ,

Contributed equally to this work with: Hebert Echenique-Rivera, Alessandro Muzzi

Affiliation Novartis Vaccines and Diagnostics, Siena, Italy
⨯
Alessandro Muzzi ,

Contributed equally to this work with: Hebert Echenique-Rivera, Alessandro Muzzi

Affiliation Novartis Vaccines and Diagnostics, Siena, Italy
⨯
Elena Del Tordello,

Affiliation Novartis Vaccines and Diagnostics, Siena, Italy
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Kate L. Seib,

Affiliation Novartis Vaccines and Diagnostics, Siena, Italy
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Patrice Francois,

Affiliation Genomic Research Laboratory, University of Geneva Hospitals (HUG), Geneva, Switzerland
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Rino Rappuoli,

Affiliation Novartis Vaccines and Diagnostics, Siena, Italy
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Mariagrazia Pizza,

Affiliation Novartis Vaccines and Diagnostics, Siena, Italy
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Davide Serruto

* E-mail: davide.serruto@novartis.com

Affiliation Novartis Vaccines and Diagnostics, Siena, Italy
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Blood
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Gene regulation
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Gene expression
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Deletion mutagenesis
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Regulator genes
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Outer membrane proteins
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Mutant strains
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Microarrays
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