A Yersinia Effector with Enhanced Inhibitory Activity on the NF-κB Pathway Activates the NLRP3/ASC/Caspase-1 Inflammasome in Macrophages

Ying Zheng; Sarit Lilo; Igor E. Brodsky; Yue Zhang; Ruslan Medzhitov; Kenneth B. Marcu; James B. Bliska

doi:10.1371/journal.ppat.1002026

Loading metrics

Open Access

Peer-reviewed

Research Article

A Yersinia Effector with Enhanced Inhibitory Activity on the NF-κB Pathway Activates the NLRP3/ASC/Caspase-1 Inflammasome in Macrophages

Ying Zheng ,

Contributed equally to this work with: Ying Zheng, Sarit Lilo

Affiliation Department of Molecular Genetics and Microbiology, Center for Infectious Diseases, Stony Brook University, Stony Brook, New York, United States of America
⨯
Sarit Lilo ,

Contributed equally to this work with: Ying Zheng, Sarit Lilo

Current address: Department of Surgery, Stony Brook University, Stony Brook, New York, United States of America.

Affiliation Department of Molecular Genetics and Microbiology, Center for Infectious Diseases, Stony Brook University, Stony Brook, New York, United States of America
⨯
Igor E. Brodsky,

Current address: Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America.

Affiliation Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Yue Zhang,

Affiliation Department of Molecular Genetics and Microbiology, Center for Infectious Diseases, Stony Brook University, Stony Brook, New York, United States of America
⨯
Ruslan Medzhitov,

Affiliation Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Kenneth B. Marcu,

Affiliations Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York, United States of America, Immunology and Genetics Department, Istituti Ortopedia Rizzoli, Bologna, Italy
⨯
James B. Bliska

* E-mail: jbliska@ms.cc.sunysb.edu

Affiliation Department of Molecular Genetics and Microbiology, Center for Infectious Diseases, Stony Brook University, Stony Brook, New York, United States of America
⨯

A Yersinia Effector with Enhanced Inhibitory Activity on the NF-κB Pathway Activates the NLRP3/ASC/Caspase-1 Inflammasome in Macrophages

Ying Zheng,
Sarit Lilo,
Igor E. Brodsky,
Yue Zhang,
Ruslan Medzhitov,
Kenneth B. Marcu,
James B. Bliska

Published: April 21, 2011
https://doi.org/10.1371/journal.ppat.1002026

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Macrophages
Is the Subject Area "Macrophages" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Yersinia pestis
Is the Subject Area "Yersinia pestis" applicable to this article?

Thanks for your feedback.
Secretion
Is the Subject Area "Secretion" applicable to this article?

Thanks for your feedback.
Yersinia pseudotuberculosis
Is the Subject Area "Yersinia pseudotuberculosis" applicable to this article?

Thanks for your feedback.
Enzyme-linked immunoassays
Is the Subject Area "Enzyme-linked immunoassays" applicable to this article?

Thanks for your feedback.
Transcription factors
Is the Subject Area "Transcription factors" applicable to this article?

Thanks for your feedback.
Inflammasomes
Is the Subject Area "Inflammasomes" applicable to this article?

Thanks for your feedback.