Rhesus TRIM5α Disrupts the HIV-1 Capsid at the Inter­Hexamer Interfaces

Gongpu Zhao; Danxia Ke; Thomas Vu; Jinwoo Ahn; Vaibhav B. Shah; Ruifeng Yang; Christopher Aiken; Lisa M. Charlton; Angela M. Gronenborn; Peijun Zhang

doi:10.1371/journal.ppat.1002009

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Peer-reviewed

Research Article

Rhesus TRIM5α Disrupts the HIV-1 Capsid at the InterHexamer Interfaces

Gongpu Zhao,

Affiliation Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Danxia Ke,

Affiliation Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Thomas Vu,

Affiliation Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Jinwoo Ahn,

Affiliation Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Vaibhav B. Shah,

Affiliation Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Ruifeng Yang,

Affiliation Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Christopher Aiken,

Affiliation Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Lisa M. Charlton,

Affiliation Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Angela M. Gronenborn,

Affiliation Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Peijun Zhang

* E-mail: pez7@pitt.edu

Affiliation Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯

Rhesus TRIM5α Disrupts the HIV-1 Capsid at the InterHexamer Interfaces

Gongpu Zhao,
Danxia Ke,
Thomas Vu,
Jinwoo Ahn,
Vaibhav B. Shah,
Ruifeng Yang,
Christopher Aiken,
Lisa M. Charlton,
Angela M. Gronenborn,
Peijun Zhang

Published: March 24, 2011
https://doi.org/10.1371/journal.ppat.1002009

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Viral packaging
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Binding analysis
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Centrifugation
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Protein domains
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Reverse transcription
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