Type I Interferon Production Induced by Streptococcus pyogenes-Derived Nucleic Acids Is Required for Host Protection

Nina Gratz; Harald Hartweger; Ulrich Matt; Franz Kratochvill; Marton Janos; Stefanie Sigel; Barbara Drobits; Xiao-Dong Li; Sylvia Knapp; Pavel Kovarik

doi:10.1371/journal.ppat.1001345

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Open Access

Peer-reviewed

Research Article

Type I Interferon Production Induced by Streptococcus pyogenes-Derived Nucleic Acids Is Required for Host Protection

Nina Gratz,

Affiliation Max F. Perutz Laboratories, Department of Microbiology, Immunobiology and Genetics, University of Vienna, Vienna, Austria
⨯
Harald Hartweger,

Affiliation Max F. Perutz Laboratories, Department of Microbiology, Immunobiology and Genetics, University of Vienna, Vienna, Austria
⨯
Ulrich Matt,

Affiliation CEMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences and Department of Internal Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria
⨯
Franz Kratochvill,

Affiliation Max F. Perutz Laboratories, Department of Microbiology, Immunobiology and Genetics, University of Vienna, Vienna, Austria
⨯
Marton Janos,

Affiliation Max F. Perutz Laboratories, Department of Microbiology, Immunobiology and Genetics, University of Vienna, Vienna, Austria
⨯
Stefanie Sigel,

Affiliation CEMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences and Department of Internal Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria
⨯
Barbara Drobits,

Affiliation Institute for Cancer Research, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria
⨯
Xiao-Dong Li,

Affiliation Department of Molecular Biology, UT Southwestern Medical Center, Dallas, Texas, United States of America
⨯
Sylvia Knapp,

Affiliation CEMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences and Department of Internal Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria
⨯
Pavel Kovarik

* E-mail: pavel.kovarik@univie.ac.at

Affiliation Max F. Perutz Laboratories, Department of Microbiology, Immunobiology and Genetics, University of Vienna, Vienna, Austria
⨯

Type I Interferon Production Induced by Streptococcus pyogenes-Derived Nucleic Acids Is Required for Host Protection

Nina Gratz,
Harald Hartweger,
Ulrich Matt,
Franz Kratochvill,
Marton Janos,
Stefanie Sigel,
Barbara Drobits,
Xiao-Dong Li,
Sylvia Knapp,
Pavel Kovarik

Published: May 19, 2011
https://doi.org/10.1371/journal.ppat.1001345

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Streptococcus pyogenes
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Immune receptor signaling
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Macrophages
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DNA isolation
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Nucleic acids
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Small interfering RNA
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Enzyme-linked immunoassays
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