A Molecular Mechanism for Eflornithine Resistance in African Trypanosomes

Isabel M. Vincent; Darren Creek; David G. Watson; Mohammed A. Kamleh; Debra J. Woods; Pui Ee Wong; Richard J. S. Burchmore; Michael P. Barrett

doi:10.1371/journal.ppat.1001204

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Research Article

A Molecular Mechanism for Eflornithine Resistance in African Trypanosomes

Isabel M. Vincent,

Affiliation Faculty of Biomedical and Life Science and Wellcome Trust Centre for Molecular Parasitology, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
⨯
Darren Creek,

Affiliation Faculty of Biomedical and Life Science and Wellcome Trust Centre for Molecular Parasitology, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
⨯
David G. Watson,

Affiliation Strathclyde Institute for Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom
⨯
Mohammed A. Kamleh,

Current address: Department of Biomolecular Medicine, Imperial College London, London, United Kingdom

Affiliation Strathclyde Institute for Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom
⨯
Debra J. Woods,

Affiliation Pfizer Animal Health, Pfizer Inc, Kalamazoo, Michigan, United States of America
⨯
Pui Ee Wong,

Affiliation Faculty of Biomedical and Life Science and Wellcome Trust Centre for Molecular Parasitology, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
⨯
Richard J. S. Burchmore,

Affiliation Faculty of Biomedical and Life Science and Wellcome Trust Centre for Molecular Parasitology, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
⨯
Michael P. Barrett

* E-mail: m.barrett@bio.gla.ac.uk

Affiliation Faculty of Biomedical and Life Science and Wellcome Trust Centre for Molecular Parasitology, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
⨯

A Molecular Mechanism for Eflornithine Resistance in African Trypanosomes

Isabel M. Vincent,
Darren Creek,
David G. Watson,
Mohammed A. Kamleh,
Debra J. Woods,
Pui Ee Wong,
Richard J. S. Burchmore,
Michael P. Barrett

Published: November 24, 2010
https://doi.org/10.1371/journal.ppat.1001204

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Trypanosoma brucei gambiense
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African trypanosomiasis
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