Crystal Structure and Size-Dependent Neutralization Properties of HK20, a Human Monoclonal Antibody Binding to the Highly Conserved Heptad Repeat 1 of gp41

Charles Sabin; Davide Corti; Victor Buzon; Mike S. Seaman; David Lutje Hulsik; Andreas Hinz; Fabrizia Vanzetta; Gloria Agatic; Chiara Silacci; Lara Mainetti; Gabriella Scarlatti; Federica Sallusto; Robin Weiss; Antonio Lanzavecchia; Winfried Weissenhorn

doi:10.1371/journal.ppat.1001195

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Peer-reviewed

Research Article

Crystal Structure and Size-Dependent Neutralization Properties of HK20, a Human Monoclonal Antibody Binding to the Highly Conserved Heptad Repeat 1 of gp41

Charles Sabin ,

Contributed equally to this work with: Charles Sabin, Davide Corti, Victor Buzon

Affiliation Unit of Virus Host Cell Interactions (UVHCI) UMI 3265, Université Joseph Fourier-EMBL-CNRS, Grenoble, France
⨯
Davide Corti ,

Contributed equally to this work with: Charles Sabin, Davide Corti, Victor Buzon

Current address: Humabs SAGL, Bellinzona, Switzerland

Affiliation Institute for Research in Biomedicine, Bellinzona, Switzerland
⨯
Victor Buzon ,

Contributed equally to this work with: Charles Sabin, Davide Corti, Victor Buzon

Affiliation Unit of Virus Host Cell Interactions (UVHCI) UMI 3265, Université Joseph Fourier-EMBL-CNRS, Grenoble, France
⨯
Mike S. Seaman,

Affiliation Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
⨯
David Lutje Hulsik,

Affiliation Unit of Virus Host Cell Interactions (UVHCI) UMI 3265, Université Joseph Fourier-EMBL-CNRS, Grenoble, France
⨯
Andreas Hinz,

Affiliation Unit of Virus Host Cell Interactions (UVHCI) UMI 3265, Université Joseph Fourier-EMBL-CNRS, Grenoble, France
⨯
Fabrizia Vanzetta,

Affiliation Humabs SAGL, Bellinzona, Switzerland
⨯
Gloria Agatic,

Affiliation Humabs SAGL, Bellinzona, Switzerland
⨯
Chiara Silacci,

Affiliation Institute for Research in Biomedicine, Bellinzona, Switzerland
⨯
Lara Mainetti,

Affiliation Viral Evolution and Transmission Unit, Division of Immunology, Transplant and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
⨯
Gabriella Scarlatti,

Affiliation Viral Evolution and Transmission Unit, Division of Immunology, Transplant and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
⨯
Federica Sallusto,

Affiliation Institute for Research in Biomedicine, Bellinzona, Switzerland
⨯
Robin Weiss,

Affiliation Division of Infection and Immunity, University College London, London, United Kingdom
⨯
Antonio Lanzavecchia,

Affiliations Institute for Research in Biomedicine, Bellinzona, Switzerland, Institute of Microbiology, Swiss Federal Institute of Technology, Zurich, Switzerland
⨯
Winfried Weissenhorn

* E-mail: weissenhorn@embl.fr

Affiliation Unit of Virus Host Cell Interactions (UVHCI) UMI 3265, Université Joseph Fourier-EMBL-CNRS, Grenoble, France
⨯

Crystal Structure and Size-Dependent Neutralization Properties of HK20, a Human Monoclonal Antibody Binding to the Highly Conserved Heptad Repeat 1 of gp41

Charles Sabin,
Davide Corti,
Victor Buzon,
Mike S. Seaman,
David Lutje Hulsik,
Andreas Hinz,
Fabrizia Vanzetta,
Gloria Agatic,
Chiara Silacci,
Lara Mainetti

Published: November 18, 2010
https://doi.org/10.1371/journal.ppat.1001195

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