Calcineurin Inhibition at the Clinical Phase of Prion Disease Reduces Neurodegeneration, Improves Behavioral Alterations and Increases Animal Survival

Abhisek Mukherjee; Diego Morales-Scheihing; Dennisse Gonzalez-Romero; Kristi Green; Giulio Taglialatela; Claudio Soto

doi:10.1371/journal.ppat.1001138

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Research Article

Calcineurin Inhibition at the Clinical Phase of Prion Disease Reduces Neurodegeneration, Improves Behavioral Alterations and Increases Animal Survival

Abhisek Mukherjee,

Affiliations Mitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, University of Texas Houston Medical School, Houston, Texas, United States of America, Department of Neurology, University of Texas Medical Branch, Galveston, Texas, United States of America
⨯
Diego Morales-Scheihing,

Affiliation Mitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, University of Texas Houston Medical School, Houston, Texas, United States of America
⨯
Dennisse Gonzalez-Romero,

Affiliations Mitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, University of Texas Houston Medical School, Houston, Texas, United States of America, Department of Neurology, University of Texas Medical Branch, Galveston, Texas, United States of America
⨯
Kristi Green,

Affiliation Department of Neurology, University of Texas Medical Branch, Galveston, Texas, United States of America
⨯
Giulio Taglialatela,

Affiliation Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas, United States of America
⨯
Claudio Soto

* E-mail: Claudio.Soto@uth.tmc.edu

Affiliations Mitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, University of Texas Houston Medical School, Houston, Texas, United States of America, Department of Neurology, University of Texas Medical Branch, Galveston, Texas, United States of America, Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas, United States of America
⨯

Calcineurin Inhibition at the Clinical Phase of Prion Disease Reduces Neurodegeneration, Improves Behavioral Alterations and Increases Animal Survival

Abhisek Mukherjee,
Diego Morales-Scheihing,
Dennisse Gonzalez-Romero,
Kristi Green,
Giulio Taglialatela,
Claudio Soto

Published: October 7, 2010
https://doi.org/10.1371/journal.ppat.1001138

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