Conformational Adaptation of Asian Macaque TRIMCyp Directs Lineage Specific Antiviral Activity

Laura M. J. Ylinen; Amanda J. Price; Jane Rasaiyaah; Stéphane Hué; Nicola J. Rose; Flavia Marzetta; Leo C. James; Greg J. Towers

doi:10.1371/journal.ppat.1001062

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Peer-reviewed

Research Article

Conformational Adaptation of Asian Macaque TRIMCyp Directs Lineage Specific Antiviral Activity

Laura M. J. Ylinen ,

Contributed equally to this work with: Laura M. J. Ylinen, Amanda J. Price

Affiliations University College London Medical Research Council Centre for Medical Molecular Virology, London, United Kingdom, Division of Infection and Immunity, University College London, London, United Kingdom
⨯
Amanda J. Price ,

Contributed equally to this work with: Laura M. J. Ylinen, Amanda J. Price

Affiliation Medical Research Council Laboratory of Molecular Biology, Protein and Nucleic Acid Chemistry Division, Cambridge, United Kingdom
⨯
Jane Rasaiyaah,

Affiliations University College London Medical Research Council Centre for Medical Molecular Virology, London, United Kingdom, Division of Infection and Immunity, University College London, London, United Kingdom
⨯
Stéphane Hué,

Affiliations University College London Medical Research Council Centre for Medical Molecular Virology, London, United Kingdom, Division of Infection and Immunity, University College London, London, United Kingdom
⨯
Nicola J. Rose,

Affiliation The National Institute for Biological Standards and Control, A Centre of the Health Protection Agency, Potters Bar, Hertfordshire, United Kingdom
⨯
Flavia Marzetta,

Current address: School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

Affiliations University College London Medical Research Council Centre for Medical Molecular Virology, London, United Kingdom, Division of Infection and Immunity, University College London, London, United Kingdom
⨯
Leo C. James ,

* E-mail: lcj@mrc-lmb.cam.ac.uk (LCJ); g.towers@ucl.ac.uk (GJT)

Affiliation Medical Research Council Laboratory of Molecular Biology, Protein and Nucleic Acid Chemistry Division, Cambridge, United Kingdom
⨯
Greg J. Towers

* E-mail: lcj@mrc-lmb.cam.ac.uk (LCJ); g.towers@ucl.ac.uk (GJT)

Affiliations University College London Medical Research Council Centre for Medical Molecular Virology, London, United Kingdom, Division of Infection and Immunity, University College London, London, United Kingdom
⨯

Conformational Adaptation of Asian Macaque TRIMCyp Directs Lineage Specific Antiviral Activity

Laura M. J. Ylinen,
Amanda J. Price,
Jane Rasaiyaah,
Stéphane Hué,
Nicola J. Rose,
Flavia Marzetta,
Leo C. James,
Greg J. Towers

Published: August 19, 2010
https://doi.org/10.1371/journal.ppat.1001062

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