The N-Terminal Domain of the Arenavirus L Protein Is an RNA Endonuclease Essential in mRNA Transcription

Benjamin Morin; Bruno Coutard; Michaela Lelke; François Ferron; Romy Kerber; Saïd Jamal; Antoine Frangeul; Cécile Baronti; Rémi Charrel; Xavier de Lamballerie; Clemens Vonrhein; Julien Lescar; Gérard Bricogne; Stephan Günther; Bruno Canard

doi:10.1371/journal.ppat.1001038

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Open Access

Peer-reviewed

Research Article

The N-Terminal Domain of the Arenavirus L Protein Is an RNA Endonuclease Essential in mRNA Transcription

Benjamin Morin,

Affiliation Architecture et Fonction des Macromolécules Biologiques, CNRS and Universités d'Aix-Marseille I et II, UMR 6098, ESIL Case 925, Marseille, France
⨯
Bruno Coutard,

Affiliation Architecture et Fonction des Macromolécules Biologiques, CNRS and Universités d'Aix-Marseille I et II, UMR 6098, ESIL Case 925, Marseille, France
⨯
Michaela Lelke,

Affiliation Department of Virology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany
⨯
François Ferron,

Affiliation Architecture et Fonction des Macromolécules Biologiques, CNRS and Universités d'Aix-Marseille I et II, UMR 6098, ESIL Case 925, Marseille, France
⨯
Romy Kerber,

Affiliation Department of Virology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany
⨯
Saïd Jamal,

Affiliation Architecture et Fonction des Macromolécules Biologiques, CNRS and Universités d'Aix-Marseille I et II, UMR 6098, ESIL Case 925, Marseille, France
⨯
Antoine Frangeul,

Affiliation Architecture et Fonction des Macromolécules Biologiques, CNRS and Universités d'Aix-Marseille I et II, UMR 6098, ESIL Case 925, Marseille, France
⨯
Cécile Baronti,

Affiliation Unité des Virus Emergents UMR190, Université de la Méditerranée & Institut de Recherche pour le Développement, Marseille, France
⨯
Rémi Charrel,

Affiliation Unité des Virus Emergents UMR190, Université de la Méditerranée & Institut de Recherche pour le Développement, Marseille, France
⨯
Xavier de Lamballerie,

Affiliation Unité des Virus Emergents UMR190, Université de la Méditerranée & Institut de Recherche pour le Développement, Marseille, France
⨯
Clemens Vonrhein,

Affiliation Global Phasing Ltd., Cambridge, United Kingdom
⨯
Julien Lescar,

Affiliations Architecture et Fonction des Macromolécules Biologiques, CNRS and Universités d'Aix-Marseille I et II, UMR 6098, ESIL Case 925, Marseille, France, School of Biological Sciences, Nanyang Technological University, Singapore, Singapore
⨯
Gérard Bricogne,

Affiliation Global Phasing Ltd., Cambridge, United Kingdom
⨯
Stephan Günther,

Affiliation Department of Virology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany
⨯
Bruno Canard

* E-mail: bruno.canard@afmb.univ-mrs.fr

Affiliation Architecture et Fonction des Macromolécules Biologiques, CNRS and Universités d'Aix-Marseille I et II, UMR 6098, ESIL Case 925, Marseille, France
⨯

The N-Terminal Domain of the Arenavirus L Protein Is an RNA Endonuclease Essential in mRNA Transcription

Benjamin Morin,
Bruno Coutard,
Michaela Lelke,
François Ferron,
Romy Kerber,
Saïd Jamal,
Antoine Frangeul,
Cécile Baronti,
Rémi Charrel,
Xavier de Lamballerie

Published: September 16, 2010
https://doi.org/10.1371/journal.ppat.1001038

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