Suppressing Glucose Transporter Gene Expression in Schistosomes Impairs Parasite Feeding and Decreases Survival in the Mammalian Host

Greice Krautz-Peterson; Mariana Simoes; Zahra Faghiri; David Ndegwa; Guilherme Oliveira; Charles B. Shoemaker; Patrick J. Skelly

doi:10.1371/journal.ppat.1000932

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Peer-reviewed

Research Article

Suppressing Glucose Transporter Gene Expression in Schistosomes Impairs Parasite Feeding and Decreases Survival in the Mammalian Host

Greice Krautz-Peterson,

Affiliation Molecular Helminthology Laboratory, Division of Infectious Diseases, Department of Biomedical Sciences, Tufts University, Cummings School of Veterinary Medicine, Grafton, Massachusetts, United States of America
⨯
Mariana Simoes,

Affiliation Laboratory of Cellular and Molecular Parasitology and CEBio, Instituto René Rachou - FIOCRUZ, Belo Horizonte, MG, Brazil
⨯
Zahra Faghiri,

Affiliation Molecular Helminthology Laboratory, Division of Infectious Diseases, Department of Biomedical Sciences, Tufts University, Cummings School of Veterinary Medicine, Grafton, Massachusetts, United States of America
⨯
David Ndegwa,

Affiliation Molecular Helminthology Laboratory, Division of Infectious Diseases, Department of Biomedical Sciences, Tufts University, Cummings School of Veterinary Medicine, Grafton, Massachusetts, United States of America
⨯
Guilherme Oliveira,

Affiliations Laboratory of Cellular and Molecular Parasitology and CEBio, Instituto René Rachou - FIOCRUZ, Belo Horizonte, MG, Brazil, Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais, Salvador, BA, Brazil
⨯
Charles B. Shoemaker,

Affiliation Molecular Helminthology Laboratory, Division of Infectious Diseases, Department of Biomedical Sciences, Tufts University, Cummings School of Veterinary Medicine, Grafton, Massachusetts, United States of America
⨯
Patrick J. Skelly

* E-mail: Patrick.Skelly@Tufts.edu

Affiliation Molecular Helminthology Laboratory, Division of Infectious Diseases, Department of Biomedical Sciences, Tufts University, Cummings School of Veterinary Medicine, Grafton, Massachusetts, United States of America
⨯

Suppressing Glucose Transporter Gene Expression in Schistosomes Impairs Parasite Feeding and Decreases Survival in the Mammalian Host

Greice Krautz-Peterson,
Mariana Simoes,
Zahra Faghiri,
David Ndegwa,
Guilherme Oliveira,
Charles B. Shoemaker,
Patrick J. Skelly

Published: June 3, 2010
https://doi.org/10.1371/journal.ppat.1000932

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Glucose
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Parasitic diseases
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Small interfering RNA
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Schistosoma
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RNA interference
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Gene expression
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Glucose transporters
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Membrane proteins
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