RNA Polymerase Activity and Specific RNA Structure Are Required for Efficient HCV Replication in Cultured Cells

Asako Murayama; Leiyun Weng; Tomoko Date; Daisuke Akazawa; Xiao Tian; Tetsuro Suzuki; Takanobu Kato; Yasuhito Tanaka; Masashi Mizokami; Takaji Wakita; Tetsuya Toyoda

doi:10.1371/journal.ppat.1000885

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Open Access

Peer-reviewed

Research Article

RNA Polymerase Activity and Specific RNA Structure Are Required for Efficient HCV Replication in Cultured Cells

Asako Murayama ,

Contributed equally to this work with: Asako Murayama, Leiyun Weng

Affiliation Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
⨯
Leiyun Weng ,

Contributed equally to this work with: Asako Murayama, Leiyun Weng

Affiliation Unit of Viral Genome Regulation, Key Laboratory of Molecular Virology & Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, People's Republic of China
⨯
Tomoko Date,

Affiliation Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
⨯
Daisuke Akazawa,

Affiliations Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan, Pharmaceutical Research Lab, Toray Industries, Inc., Kanagawa, Japan
⨯
Xiao Tian,

Affiliation Unit of Viral Genome Regulation, Key Laboratory of Molecular Virology & Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, People's Republic of China
⨯
Tetsuro Suzuki,

Affiliation Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
⨯
Takanobu Kato,

Affiliation Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
⨯
Yasuhito Tanaka,

Affiliation Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan
⨯
Masashi Mizokami,

Affiliation Research Center for Hepatitis and Immunology, Kohnodai Hospital, International Medical Center of Japan, Chiba, Japan
⨯
Takaji Wakita ,

* E-mail: wakita@nih.go.jp (TW); ttoyoda@sibs.ac.cn (TT)

Affiliation Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
⨯
Tetsuya Toyoda

* E-mail: wakita@nih.go.jp (TW); ttoyoda@sibs.ac.cn (TT)

Affiliation Unit of Viral Genome Regulation, Key Laboratory of Molecular Virology & Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, People's Republic of China
⨯

RNA Polymerase Activity and Specific RNA Structure Are Required for Efficient HCV Replication in Cultured Cells

Asako Murayama,
Leiyun Weng,
Tomoko Date,
Daisuke Akazawa,
Xiao Tian,
Tetsuro Suzuki,
Takanobu Kato,
Yasuhito Tanaka,
Masashi Mizokami,
Takaji Wakita

Published: April 29, 2010
https://doi.org/10.1371/journal.ppat.1000885

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Viral replication
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Polymerases
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RNA structure
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