Perforin and IL-2 Upregulation Define Qualitative Differences among Highly Functional Virus-Specific Human CD8+ T Cells

George Makedonas; Natalie Hutnick; Danielle Haney; Alexandra C. Amick; Jay Gardner; Gabriela Cosma; Adam R. Hersperger; Douglas Dolfi; E. John Wherry; Guido Ferrari; Michael R. Betts

doi:10.1371/journal.ppat.1000798

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Peer-reviewed

Research Article

Perforin and IL-2 Upregulation Define Qualitative Differences among Highly Functional Virus-Specific Human CD8⁺ T Cells

George Makedonas,

Affiliation Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Natalie Hutnick,

Affiliation Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Danielle Haney,

Affiliation Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Alexandra C. Amick,

Affiliation Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Jay Gardner,

Affiliation Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Gabriela Cosma,

Affiliation Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Adam R. Hersperger,

Affiliation Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Douglas Dolfi,

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯
E. John Wherry,

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯
Guido Ferrari,

Affiliation Department of Surgical Sciences, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Michael R. Betts

* E-mail: betts@mail.med.upenn.edu

Affiliation Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯

Perforin and IL-2 Upregulation Define Qualitative Differences among Highly Functional Virus-Specific Human CD8⁺ T Cells

George Makedonas,
Natalie Hutnick,
Danielle Haney,
Alexandra C. Amick,
Jay Gardner,
Gabriela Cosma,
Adam R. Hersperger,
Douglas Dolfi,
E. John Wherry,
Guido Ferrari

Published: March 5, 2010
https://doi.org/10.1371/journal.ppat.1000798

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