HIV Controller CD4+ T Cells Respond to Minimal Amounts of Gag Antigen Due to High TCR Avidity

Benoît Vingert; Santiago Perez-Patrigeon; Patricia Jeannin; Olivier Lambotte; Faroudy Boufassa; Fabrice Lemaître; William W. Kwok; Ioannis Theodorou; Jean-François Delfraissy; Jacques Thèze; Lisa A. Chakrabarti; for the ANRS EP36 HIV Controllers Study Group

doi:10.1371/journal.ppat.1000780

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Open Access

Peer-reviewed

Research Article

HIV Controller CD4+ T Cells Respond to Minimal Amounts of Gag Antigen Due to High TCR Avidity

Benoît Vingert,

Affiliation Unité d'Immunogénétique Cellulaire, Institut Pasteur, Paris, France
⨯
Santiago Perez-Patrigeon ,

Contributed equally to this work with: Santiago Perez-Patrigeon, Patricia Jeannin

Affiliation Unité d'Immunogénétique Cellulaire, Institut Pasteur, Paris, France
⨯
Patricia Jeannin ,

Contributed equally to this work with: Santiago Perez-Patrigeon, Patricia Jeannin

Affiliation Unité d'Immunogénétique Cellulaire, Institut Pasteur, Paris, France
⨯
Olivier Lambotte,

Affiliations Institut National de la Santé et de la Recherche Médicale (INSERM) U802, Le Kremlin-Bicêtre, France, Assistance Publique - Hôpitaux de Paris (AP-HP), Department of Internal Medicine and Infectious Diseases, Bicêtre Hospital, Le Kremlin-Bicêtre, France, Université Paris-Sud, Le Kremlin-Bicêtre, France
⨯
Faroudy Boufassa,

Affiliation INSERM U822, Bicêtre Hospital, Le Kremlin-Bicêtre, France
⨯
Fabrice Lemaître,

Affiliations G5 Dynamiques des Réponses Immunes, Institut Pasteur, Paris, France, INSERM U668, Equipe Avenir, Institut Pasteur, Paris, France
⨯
William W. Kwok,

Affiliation Benaroya Research Institute at Virginia Mason, Seattle, Washington, United States of America
⨯
Ioannis Theodorou,

Affiliation INSERM U543, Pitié-Salpêtrière Hospital, Paris, France
⨯
Jean-François Delfraissy,

Affiliations Institut National de la Santé et de la Recherche Médicale (INSERM) U802, Le Kremlin-Bicêtre, France, Assistance Publique - Hôpitaux de Paris (AP-HP), Department of Internal Medicine and Infectious Diseases, Bicêtre Hospital, Le Kremlin-Bicêtre, France, Université Paris-Sud, Le Kremlin-Bicêtre, France
⨯
Jacques Thèze,

Affiliation Unité d'Immunogénétique Cellulaire, Institut Pasteur, Paris, France
⨯
Lisa A. Chakrabarti ,

* E-mail: chakra@pasteur.fr

Affiliation Unité d'Immunogénétique Cellulaire, Institut Pasteur, Paris, France
⨯
for the ANRS EP36 HIV Controllers Study Group

HIV Controller CD4+ T Cells Respond to Minimal Amounts of Gag Antigen Due to High TCR Avidity

Benoît Vingert,
Santiago Perez-Patrigeon,
Patricia Jeannin,
Olivier Lambotte,
Faroudy Boufassa,
Fabrice Lemaître,
William W. Kwok,
Ioannis Theodorou,
Jean-François Delfraissy,
Jacques Thèze

Published: February 26, 2010
https://doi.org/10.1371/journal.ppat.1000780

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