Parasite-Derived Plasma Microparticles Contribute Significantly to Malaria Infection-Induced Inflammation through Potent Macrophage Stimulation

Kevin N. Couper; Tom Barnes; Julius C. R. Hafalla; Valery Combes; Bernhard Ryffel; Thomas Secher; Georges E. Grau; Eleanor M. Riley; J. Brian de Souza

doi:10.1371/journal.ppat.1000744

Loading metrics

Open Access

Peer-reviewed

Research Article

Parasite-Derived Plasma Microparticles Contribute Significantly to Malaria Infection-Induced Inflammation through Potent Macrophage Stimulation

Kevin N. Couper ,

* E-mail: kevin.couper@lshtm.ac.uk (KNC); brian.desouza@lshtm.ac.uk (JBdS)

Affiliation Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Tom Barnes,

Affiliations Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom, Department of Immunology and Molecular Pathology, University College London Medical School, London, United Kingdom
⨯
Julius C. R. Hafalla,

Affiliation Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Valery Combes,

Affiliation Department of Pathology, University of Sydney, Camperdown, New South Wales, Australia
⨯
Bernhard Ryffel,

Affiliation Molecular Immunology and Embryology, University of Orleans and Centre National de la Recherche Scientifique, Orleans, France
⨯
Thomas Secher,

Affiliation Molecular Immunology and Embryology, University of Orleans and Centre National de la Recherche Scientifique, Orleans, France
⨯
Georges E. Grau,

Affiliation Department of Pathology, University of Sydney, Camperdown, New South Wales, Australia
⨯
Eleanor M. Riley,

Affiliation Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
J. Brian de Souza

* E-mail: kevin.couper@lshtm.ac.uk (KNC); brian.desouza@lshtm.ac.uk (JBdS)

Affiliations Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom, Department of Immunology and Molecular Pathology, University College London Medical School, London, United Kingdom
⨯

Parasite-Derived Plasma Microparticles Contribute Significantly to Malaria Infection-Induced Inflammation through Potent Macrophage Stimulation

Kevin N. Couper,
Tom Barnes,
Julius C. R. Hafalla,
Valery Combes,
Bernhard Ryffel,
Thomas Secher,
Georges E. Grau,
Eleanor M. Riley,
J. Brian de Souza

Published: January 29, 2010
https://doi.org/10.1371/journal.ppat.1000744

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Macrophages
Is the Subject Area "Macrophages" applicable to this article?

Thanks for your feedback.
Parasitic diseases
Is the Subject Area "Parasitic diseases" applicable to this article?

Thanks for your feedback.
Malaria
Is the Subject Area "Malaria" applicable to this article?

Thanks for your feedback.
Malarial parasites
Is the Subject Area "Malarial parasites" applicable to this article?

Thanks for your feedback.
Inflammation
Is the Subject Area "Inflammation" applicable to this article?

Thanks for your feedback.
Plasmodium
Is the Subject Area "Plasmodium" applicable to this article?

Thanks for your feedback.
Flow cytometry
Is the Subject Area "Flow cytometry" applicable to this article?

Thanks for your feedback.
Red blood cells
Is the Subject Area "Red blood cells" applicable to this article?

Thanks for your feedback.