The E3 Ubiquitin Ligase Triad3A Negatively Regulates the RIG-I/MAVS Signaling Pathway by Targeting TRAF3 for Degradation

Peyman Nakhaei; Thibault Mesplede; Mayra Solis; Qiang Sun; Tiejun Zhao; Long Yang; Tsung-Hsien Chuang; Carl F. Ware; Rongtuan Lin; John Hiscott

doi:10.1371/journal.ppat.1000650

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Open Access

Peer-reviewed

Research Article

The E3 Ubiquitin Ligase Triad3A Negatively Regulates the RIG-I/MAVS Signaling Pathway by Targeting TRAF3 for Degradation

Peyman Nakhaei,

Affiliations The Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada, Department of Microbiology & Immunology, McGill University, Montreal, Quebec, Canada
⨯
Thibault Mesplede,

Affiliations The Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada, Department of Medicine, McGill University, Montreal, Quebec, Canada
⨯
Mayra Solis,

Affiliations The Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada, Department of Microbiology & Immunology, McGill University, Montreal, Quebec, Canada
⨯
Qiang Sun,

Affiliation The Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
⨯
Tiejun Zhao,

Affiliation The Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
⨯
Long Yang,

Affiliation The Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
⨯
Tsung-Hsien Chuang,

Affiliation Department of Immunology, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Carl F. Ware,

Affiliation The Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California, United States of America
⨯
Rongtuan Lin,

Affiliations The Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada, Department of Medicine, McGill University, Montreal, Quebec, Canada
⨯
John Hiscott

* E-mail: john.hiscott@mcgill.ca

Affiliations The Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada, Department of Microbiology & Immunology, McGill University, Montreal, Quebec, Canada, Department of Medicine, McGill University, Montreal, Quebec, Canada
⨯

The E3 Ubiquitin Ligase Triad3A Negatively Regulates the RIG-I/MAVS Signaling Pathway by Targeting TRAF3 for Degradation

Peyman Nakhaei,
Thibault Mesplede,
Mayra Solis,
Qiang Sun,
Tiejun Zhao,
Long Yang,
Tsung-Hsien Chuang,
Carl F. Ware,
Rongtuan Lin,
John Hiscott

Published: November 6, 2009
https://doi.org/10.1371/journal.ppat.1000650

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