Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

• Marina Tiemi Shio,

  Affiliation Department of Medicine, Microbiology and Immunology, Centre for the Study of Host Resistance, The Research Institute of the McGill University Health Centre, Montréal, Quebec, Canada

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• Stephanie C. Eisenbarth,

  Affiliations Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America

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• Myriam Savaria,

  Affiliation Department of Medicine, Microbiology and Immunology, Centre for the Study of Host Resistance, The Research Institute of the McGill University Health Centre, Montréal, Quebec, Canada

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• Adrien F. Vinet,

  Affiliation Institut National de la Recherche Scientifique-Institut Armand-Frappier, Laval, Quebec, Canada

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• Marie-Josée Bellemare,

  Affiliations Department of Medicine, Microbiology and Immunology, Centre for the Study of Host Resistance, The Research Institute of the McGill University Health Centre, Montréal, Quebec, Canada, Department of Chemistry, McGill University, Montréal, Quebec, Canada

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• Kenneth W. Harder,

  Affiliation Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada

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• Fayyaz S. Sutterwala,

  Affiliation Inflammation Program, Department of Medicine, University of Iowa, Iowa City, Iowa, United States of America

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• D. Scott Bohle,

  Affiliation Department of Chemistry, McGill University, Montréal, Quebec, Canada

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• Albert Descoteaux,

  Affiliation Institut National de la Recherche Scientifique-Institut Armand-Frappier, Laval, Quebec, Canada

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• Richard A. Flavell,

  Affiliations Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, United States of America

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• Martin Olivier

  * E-mail: martin.olivier@mcgill.ca

  Affiliation Department of Medicine, Microbiology and Immunology, Centre for the Study of Host Resistance, The Research Institute of the McGill University Health Centre, Montréal, Quebec, Canada

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