The Two-Domain LysX Protein of Mycobacterium tuberculosis Is Required for Production of Lysinylated Phosphatidylglycerol and Resistance to Cationic Antimicrobial Peptides

Erin Maloney; Dorota Stankowska; Jian Zhang; Marek Fol; Qi-Jian Cheng; Shichun Lun; William R. Bishai; Malini Rajagopalan; Delphi Chatterjee; Murty V. Madiraju

doi:10.1371/journal.ppat.1000534

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Open Access

Peer-reviewed

Research Article

The Two-Domain LysX Protein of Mycobacterium tuberculosis Is Required for Production of Lysinylated Phosphatidylglycerol and Resistance to Cationic Antimicrobial Peptides

Erin Maloney ,

Contributed equally to this work with: Erin Maloney, Dorota Stankowska

Affiliation Department of Biochemistry, The University of Texas Health Center at Tyler, Tyler, Texas, United States of America
⨯
Dorota Stankowska ,

Contributed equally to this work with: Erin Maloney, Dorota Stankowska

Affiliation Department of Biochemistry, The University of Texas Health Center at Tyler, Tyler, Texas, United States of America
⨯
Jian Zhang,

Affiliation Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America
⨯
Marek Fol,

Current address: Department of Immunology and Infectious Biology, University of Lodz, Lodz, Poland

Affiliation Department of Biochemistry, The University of Texas Health Center at Tyler, Tyler, Texas, United States of America
⨯
Qi-Jian Cheng,

Affiliation Department of Medicine; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Shichun Lun,

Affiliation Department of Medicine; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
William R. Bishai,

Affiliation Department of Medicine; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Malini Rajagopalan,

Affiliation Department of Biochemistry, The University of Texas Health Center at Tyler, Tyler, Texas, United States of America
⨯
Delphi Chatterjee,

Affiliation Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America
⨯
Murty V. Madiraju

* E-mail: murty.madiraju@uthct.edu

Affiliation Department of Biochemistry, The University of Texas Health Center at Tyler, Tyler, Texas, United States of America
⨯

The Two-Domain LysX Protein of Mycobacterium tuberculosis Is Required for Production of Lysinylated Phosphatidylglycerol and Resistance to Cationic Antimicrobial Peptides

Erin Maloney,
Dorota Stankowska,
Jian Zhang,
Marek Fol,
Qi-Jian Cheng,
Shichun Lun,
William R. Bishai,
Malini Rajagopalan,
Delphi Chatterjee,
Murty V. Madiraju

Published: July 31, 2009
https://doi.org/10.1371/journal.ppat.1000534

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