Intravenous Inoculation of a Bat-Associated Rabies Virus Causes Lethal Encephalopathy in Mice through Invasion of the Brain via Neurosecretory Hypothalamic Fibers

Mirjam A. R. Preuss; Marie-Luise Faber; Gene S. Tan; Michael Bette; Bernhard Dietzschold; Eberhard Weihe; Matthias J. Schnell

doi:10.1371/journal.ppat.1000485

Loading metrics

Open Access

Peer-reviewed

Research Article

Intravenous Inoculation of a Bat-Associated Rabies Virus Causes Lethal Encephalopathy in Mice through Invasion of the Brain via Neurosecretory Hypothalamic Fibers

Mirjam A. R. Preuss,

Affiliations Institute of Anatomy and Cell Biology, Department of Molecular Neuroscience, Philipps University Marburg, Marburg, Germany, Jefferson Vaccine Center, Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Marie-Luise Faber,

Affiliation Jefferson Vaccine Center, Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Gene S. Tan,

Affiliation Jefferson Vaccine Center, Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Michael Bette,

Affiliation Institute of Anatomy and Cell Biology, Department of Molecular Neuroscience, Philipps University Marburg, Marburg, Germany
⨯
Bernhard Dietzschold,

Affiliation Jefferson Vaccine Center, Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Eberhard Weihe ,

Contributed equally to this work with: Eberhard Weihe, Matthias J. Schnell

Affiliation Institute of Anatomy and Cell Biology, Department of Molecular Neuroscience, Philipps University Marburg, Marburg, Germany
⨯
Matthias J. Schnell

Contributed equally to this work with: Eberhard Weihe, Matthias J. Schnell

* E-mail: matthias.schnell@jefferson.edu

Affiliation Jefferson Vaccine Center, Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯

Intravenous Inoculation of a Bat-Associated Rabies Virus Causes Lethal Encephalopathy in Mice through Invasion of the Brain via Neurosecretory Hypothalamic Fibers

Mirjam A. R. Preuss,
Marie-Luise Faber,
Gene S. Tan,
Michael Bette,
Bernhard Dietzschold,
Eberhard Weihe,
Matthias J. Schnell

Published: June 19, 2009
https://doi.org/10.1371/journal.ppat.1000485

Reader Comments (1)

Post a new comment on this article

0 Responses

08 Feb 2010
07:07 GMT
Most Recent

Rabies virus: route of dissemination. Posted by ricardo_mendes on 08 Feb 2010 at 07:07 GMT

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Central nervous system
Is the Subject Area "Central nervous system" applicable to this article?

Thanks for your feedback.
Sedentary behavior
Is the Subject Area "Sedentary behavior" applicable to this article?

Thanks for your feedback.
Spinal cord
Is the Subject Area "Spinal cord" applicable to this article?

Thanks for your feedback.
Nerve fibers
Is the Subject Area "Nerve fibers" applicable to this article?

Thanks for your feedback.
Rabies virus
Is the Subject Area "Rabies virus" applicable to this article?

Thanks for your feedback.
Viral structure
Is the Subject Area "Viral structure" applicable to this article?

Thanks for your feedback.
Immunohistochemical analysis
Is the Subject Area "Immunohistochemical analysis" applicable to this article?

Thanks for your feedback.
Neurons
Is the Subject Area "Neurons" applicable to this article?

Thanks for your feedback.