Production of Infectious Genotype 1b Virus Particles in Cell Culture and Impairment by Replication Enhancing Mutations

• Thomas Pietschmann,

  Current address: Division of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany

  Affiliation Department of Molecular Virology, University of Heidelberg, Heidelberg, Germany

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• Margarita Zayas,

  Affiliation Department of Molecular Virology, University of Heidelberg, Heidelberg, Germany

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• Philip Meuleman,

  Affiliation Center for Vaccinology, Ghent University and Hospital, Ghent, Belgium

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• Gang Long,

  Affiliation Department of Molecular Virology, University of Heidelberg, Heidelberg, Germany

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• Nicole Appel,

  Current address: EMBL Heidelberg, Cell Biology/Cell Biophysics Programme, Heidelberg, Germany

  Affiliation Department of Molecular Virology, University of Heidelberg, Heidelberg, Germany

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• George Koutsoudakis,

  Current address: Viral Hepatitis Laboratory, CIBERehd, IDIBAPS, Hospital Clínic, Barcelona, Spain

  Affiliation Department of Molecular Virology, University of Heidelberg, Heidelberg, Germany

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• Stephanie Kallis,

  Affiliation Department of Molecular Virology, University of Heidelberg, Heidelberg, Germany

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• Geert Leroux-Roels,

  Affiliation Center for Vaccinology, Ghent University and Hospital, Ghent, Belgium

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• Volker Lohmann,

  Affiliation Department of Molecular Virology, University of Heidelberg, Heidelberg, Germany

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• Ralf Bartenschlager

  * E-mail: Ralf_Bartenschlager@med.uni-heidelberg.de

  Affiliation Department of Molecular Virology, University of Heidelberg, Heidelberg, Germany

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