The SARS-Unique Domain (SUD) of SARS Coronavirus Contains Two Macrodomains That Bind G-Quadruplexes

Jinzhi Tan; Clemens Vonrhein; Oliver S. Smart; Gerard Bricogne; Michela Bollati; Yuri Kusov; Guido Hansen; Jeroen R. Mesters; Christian L. Schmidt; Rolf Hilgenfeld

doi:10.1371/journal.ppat.1000428

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Peer-reviewed

Research Article

The SARS-Unique Domain (SUD) of SARS Coronavirus Contains Two Macrodomains That Bind G-Quadruplexes

Jinzhi Tan,

Affiliation Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Lübeck, Germany
⨯
Clemens Vonrhein,

Affiliation Global Phasing Ltd., Sheraton House, Castle Park, Cambridge, United Kingdom
⨯
Oliver S. Smart,

Affiliation Global Phasing Ltd., Sheraton House, Castle Park, Cambridge, United Kingdom
⨯
Gerard Bricogne,

Affiliation Global Phasing Ltd., Sheraton House, Castle Park, Cambridge, United Kingdom
⨯
Michela Bollati ,

¶On leave from the Department of Biomolecular Sciences & Biotechnology, University of Milan, Milano, Italy

Affiliation Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Lübeck, Germany
⨯
Yuri Kusov,

Affiliation Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Lübeck, Germany
⨯
Guido Hansen,

Affiliation Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Lübeck, Germany
⨯
Jeroen R. Mesters,

Affiliation Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Lübeck, Germany
⨯
Christian L. Schmidt,

Affiliation Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Lübeck, Germany
⨯
Rolf Hilgenfeld

* E-mail: hilgenfeld@biochem.uni-luebeck.de

Affiliations Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Lübeck, Germany, Laboratory for Structural Biology of Infection and Inflammation, c/o DESY, Hamburg, Germany
⨯

The SARS-Unique Domain (SUD) of SARS Coronavirus Contains Two Macrodomains That Bind G-Quadruplexes

Jinzhi Tan,
Clemens Vonrhein,
Oliver S. Smart,
Gerard Bricogne,
Michela Bollati,
Yuri Kusov,
Guido Hansen,
Jeroen R. Mesters,
Christian L. Schmidt,
Rolf Hilgenfeld

Published: May 15, 2009
https://doi.org/10.1371/journal.ppat.1000428

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