Early Onset Prion Disease from Octarepeat Expansion Correlates with Copper Binding Properties

Open Access

Peer-reviewed

Research Article

Daniel J. Stevens,

Affiliation Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California, United States of America
⨯
Eric D. Walter,

Affiliation Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California, United States of America
⨯
Abel Rodríguez,

Affiliation Department of Applied Mathematics and Statistics, University of California Santa Cruz, Santa Cruz, California, United States of America
⨯
David Draper,

Affiliation Department of Applied Mathematics and Statistics, University of California Santa Cruz, Santa Cruz, California, United States of America
⨯
Paul Davies,

Affiliation Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom
⨯
David R. Brown,

Affiliation Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom
⨯
Glenn L. Millhauser

* E-mail: glennm@chemistry.ucsc.edu

Affiliation Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California, United States of America
⨯

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Prion diseases
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Animal prion diseases
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Copper
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Insertion mutation
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Histidine
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Electron spin resonance spectroscopy
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Glutathione
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Protein domains
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