Distinct Roles for FOXP3+ and FOXP3− CD4+ T Cells in Regulating Cellular Immunity to Uncomplicated and Severe Plasmodium falciparum Malaria

Michael Walther; David Jeffries; Olivia C. Finney; Madi Njie; Augustine Ebonyi; Susanne Deininger; Emma Lawrence; Alfred Ngwa-Amambua; Shamanthi Jayasooriya; Ian H. Cheeseman; Natalia Gomez-Escobar; Joseph Okebe; David J. Conway; Eleanor M. Riley

doi:10.1371/journal.ppat.1000364

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Open Access

Peer-reviewed

Research Article

Distinct Roles for FOXP3⁺ and FOXP3⁻ CD4⁺ T Cells in Regulating Cellular Immunity to Uncomplicated and Severe Plasmodium falciparum Malaria

Michael Walther ,

* E-mail: mwalther@mrc.gm

Affiliation Medical Research Council Laboratories, Fajara, Banjul, The Gambia
⨯
David Jeffries,

Affiliation Medical Research Council Laboratories, Fajara, Banjul, The Gambia
⨯
Olivia C. Finney,

Affiliations Medical Research Council Laboratories, Fajara, Banjul, The Gambia, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Madi Njie,

Affiliation Medical Research Council Laboratories, Fajara, Banjul, The Gambia
⨯
Augustine Ebonyi,

Affiliation Medical Research Council Laboratories, Fajara, Banjul, The Gambia
⨯
Susanne Deininger,

Affiliations Medical Research Council Laboratories, Fajara, Banjul, The Gambia, Institute of Medical Microbiology, Immunology and Parasitology, University Clinic Bonn, Bonn, Germany
⨯
Emma Lawrence,

Affiliation Medical Research Council Laboratories, Fajara, Banjul, The Gambia
⨯
Alfred Ngwa-Amambua,

Affiliation Medical Research Council Laboratories, Fajara, Banjul, The Gambia
⨯
Shamanthi Jayasooriya,

Affiliation Medical Research Council Laboratories, Fajara, Banjul, The Gambia
⨯
Ian H. Cheeseman,

Affiliations Medical Research Council Laboratories, Fajara, Banjul, The Gambia, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Natalia Gomez-Escobar,

Affiliation Medical Research Council Laboratories, Fajara, Banjul, The Gambia
⨯
Joseph Okebe,

Affiliation Medical Research Council Laboratories, Fajara, Banjul, The Gambia
⨯
David J. Conway,

Affiliations Medical Research Council Laboratories, Fajara, Banjul, The Gambia, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Eleanor M. Riley

Affiliation Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯

Distinct Roles for FOXP3⁺ and FOXP3⁻ CD4⁺ T Cells in Regulating Cellular Immunity to Uncomplicated and Severe Plasmodium falciparum Malaria

Michael Walther,
David Jeffries,
Olivia C. Finney,
Madi Njie,
Augustine Ebonyi,
Susanne Deininger,
Emma Lawrence,
Alfred Ngwa-Amambua,
Shamanthi Jayasooriya,
Ian H. Cheeseman

Published: April 3, 2009
https://doi.org/10.1371/journal.ppat.1000364

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