Caspase-7 Activation by the Nlrc4/Ipaf Inflammasome Restricts Legionella pneumophila Infection

Anwari Akhter; Mikhail A. Gavrilin; Laura Frantz; Songcerae Washington; Cameron Ditty; Dominique Limoli; Colby Day; Anasuya Sarkar; Christie Newland; Jonathan Butchar; Clay B. Marsh; Mark D. Wewers; Susheela Tridandapani; Thirumala-Devi Kanneganti; Amal O. Amer

doi:10.1371/journal.ppat.1000361

Loading metrics

Open Access

Peer-reviewed

Research Article

Caspase-7 Activation by the Nlrc4/Ipaf Inflammasome Restricts Legionella pneumophila Infection

Anwari Akhter,

Affiliation Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University, Columbus, Ohio, United States of America
⨯
Mikhail A. Gavrilin,

Affiliation Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University, Columbus, Ohio, United States of America
⨯
Laura Frantz,

Affiliation Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University, Columbus, Ohio, United States of America
⨯
Songcerae Washington,

Affiliation Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University, Columbus, Ohio, United States of America
⨯
Cameron Ditty,

Affiliation Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University, Columbus, Ohio, United States of America
⨯
Dominique Limoli,

Affiliation Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University, Columbus, Ohio, United States of America
⨯
Colby Day,

Affiliation Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University, Columbus, Ohio, United States of America
⨯
Anasuya Sarkar,

Affiliation Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University, Columbus, Ohio, United States of America
⨯
Christie Newland,

Affiliation Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University, Columbus, Ohio, United States of America
⨯
Jonathan Butchar,

Affiliation Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University, Columbus, Ohio, United States of America
⨯
Clay B. Marsh,

Affiliation Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University, Columbus, Ohio, United States of America
⨯
Mark D. Wewers,

Affiliation Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University, Columbus, Ohio, United States of America
⨯
Susheela Tridandapani,

Affiliation Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University, Columbus, Ohio, United States of America
⨯
Thirumala-Devi Kanneganti ,

* E-mail: Thirumala-Devi.Kanneganti@StJude.org (TDK); amal.amer@osumc.edu (AOA)

Affiliation Department of Immunology, St Jude Children's Research Hospital, Memphis, Tennessee, United States of America
⨯
Amal O. Amer

* E-mail: Thirumala-Devi.Kanneganti@StJude.org (TDK); amal.amer@osumc.edu (AOA)

Affiliation Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University, Columbus, Ohio, United States of America
⨯

Caspase-7 Activation by the Nlrc4/Ipaf Inflammasome Restricts Legionella pneumophila Infection

Anwari Akhter,
Mikhail A. Gavrilin,
Laura Frantz,
Songcerae Washington,
Cameron Ditty,
Dominique Limoli,
Colby Day,
Anasuya Sarkar,
Christie Newland,
Jonathan Butchar

Published: April 3, 2009
https://doi.org/10.1371/journal.ppat.1000361

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Legionella pneumophila
Is the Subject Area "Legionella pneumophila" applicable to this article?

Thanks for your feedback.
Macrophages
Is the Subject Area "Macrophages" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Flagellin
Is the Subject Area "Flagellin" applicable to this article?

Thanks for your feedback.
Lysosomes
Is the Subject Area "Lysosomes" applicable to this article?

Thanks for your feedback.
Salmonellosis
Is the Subject Area "Salmonellosis" applicable to this article?

Thanks for your feedback.
Intracellular pathogens
Is the Subject Area "Intracellular pathogens" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.