Soluble CD4 and CD4-Mimetic Compounds Inhibit HIV-1 Infection by Induction of a Short-Lived Activated State

Hillel Haim; Zhihai Si; Navid Madani; Liping Wang; Joel R. Courter; Amy Princiotto; Aemro Kassa; Marciella DeGrace; Kathleen McGee-Estrada; Megan Mefford; Dana Gabuzda; Amos B. Smith III; Joseph Sodroski

doi:10.1371/journal.ppat.1000360

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Peer-reviewed

Research Article

Soluble CD4 and CD4-Mimetic Compounds Inhibit HIV-1 Infection by Induction of a Short-Lived Activated State

Hillel Haim,

Affiliation Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Zhihai Si,

Affiliation Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Navid Madani,

Affiliation Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, Massachusetts, United States of America
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Liping Wang,

Affiliation Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Joel R. Courter,

Affiliation Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Amy Princiotto,

Affiliation Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Aemro Kassa,

Affiliation Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Marciella DeGrace,

Affiliation Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, Massachusetts, United States of America
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Kathleen McGee-Estrada,

Affiliation Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Megan Mefford,

Affiliation Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Dana Gabuzda,

Affiliation Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Amos B. Smith III,

Affiliation Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Joseph Sodroski

* E-mail: joseph_sodroski@dfci.harvard.edu

Affiliations Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
⨯

Soluble CD4 and CD4-Mimetic Compounds Inhibit HIV-1 Infection by Induction of a Short-Lived Activated State

Hillel Haim,
Zhihai Si,
Navid Madani,
Liping Wang,
Joel R. Courter,
Amy Princiotto,
Aemro Kassa,
Marciella DeGrace,
Kathleen McGee-Estrada,
Megan Mefford

Published: April 3, 2009
https://doi.org/10.1371/journal.ppat.1000360

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