Functional Analysis of the Leading Malaria Vaccine Candidate AMA-1 Reveals an Essential Role for the Cytoplasmic Domain in the Invasion Process

Moritz Treeck; Sonja Zacherl; Susann Herrmann; Ana Cabrera; Maya Kono; Nicole S. Struck; Klemens Engelberg; Silvia Haase; Friedrich Frischknecht; Kota Miura; Tobias Spielmann; Tim W. Gilberger

doi:10.1371/journal.ppat.1000322

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Open Access

Peer-reviewed

Research Article

Functional Analysis of the Leading Malaria Vaccine Candidate AMA-1 Reveals an Essential Role for the Cytoplasmic Domain in the Invasion Process

Moritz Treeck,

Affiliation Department of Molecular Parasitology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany
⨯
Sonja Zacherl,

Affiliation Department of Molecular Parasitology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany
⨯
Susann Herrmann,

Affiliation Department of Molecular Parasitology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany
⨯
Ana Cabrera,

Affiliation Department of Molecular Parasitology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany
⨯
Maya Kono,

Affiliation Department of Molecular Parasitology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany
⨯
Nicole S. Struck,

Affiliation Department of Molecular Parasitology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany
⨯
Klemens Engelberg,

Affiliation Department of Molecular Parasitology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany
⨯
Silvia Haase,

Affiliation Department of Molecular Parasitology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany
⨯
Friedrich Frischknecht,

Affiliation Hygiene Institut, Abteilung Parasitologie, Universitätsklinikum Heidelberg, Heidelberg, Germany
⨯
Kota Miura,

Affiliation Centre for Molecular and Cellular Imaging, EMBL, Heidelberg, Germany
⨯
Tobias Spielmann,

Affiliation Department of Molecular Parasitology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany
⨯
Tim W. Gilberger

* E-mail: gilberger@bni-hamburg.de

Affiliation Department of Molecular Parasitology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany
⨯

Functional Analysis of the Leading Malaria Vaccine Candidate AMA-1 Reveals an Essential Role for the Cytoplasmic Domain in the Invasion Process

Moritz Treeck,
Sonja Zacherl,
Susann Herrmann,
Ana Cabrera,
Maya Kono,
Nicole S. Struck,
Klemens Engelberg,
Silvia Haase,
Friedrich Frischknecht,
Kota Miura

Published: March 6, 2009
https://doi.org/10.1371/journal.ppat.1000322

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