Genetic Variation in OAS1 Is a Risk Factor for Initial Infection with West Nile Virus in Man

Jean K. Lim; Andrea Lisco; David H. McDermott; Linda Huynh; Jerrold M. Ward; Bernard Johnson; Hope Johnson; John Pape; Gregory A. Foster; David Krysztof; Dean Follmann; Susan L. Stramer; Leonid B. Margolis; Philip M. Murphy

doi:10.1371/journal.ppat.1000321

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Open Access

Peer-reviewed

Research Article

Genetic Variation in OAS1 Is a Risk Factor for Initial Infection with West Nile Virus in Man

Jean K. Lim,

Affiliation Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Andrea Lisco,

Affiliation Section on Intercellular Interactions, Laboratory of Cellular and Molecular Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
David H. McDermott,

Affiliation Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Linda Huynh,

Affiliation Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Jerrold M. Ward,

Affiliation Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
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Bernard Johnson,

Affiliation Illinois Department of Public Health, Division of Laboratories, Chicago, Illinois, United States of America
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Hope Johnson,

Affiliation Illinois Department of Public Health, Division of Laboratories, Chicago, Illinois, United States of America
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John Pape,

Affiliation Colorado Department of Public Health and Environment, Denver, Colorado, United States of America
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Gregory A. Foster,

Affiliation Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
David Krysztof,

Affiliation Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Dean Follmann,

Affiliation American Red Cross, Gaithersburg, Maryland, United States of America
⨯
Susan L. Stramer,

Affiliation Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Leonid B. Margolis,

Affiliation Section on Intercellular Interactions, Laboratory of Cellular and Molecular Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Philip M. Murphy

* E-mail: pmm@nih.gov

Affiliation Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

Genetic Variation in OAS1 Is a Risk Factor for Initial Infection with West Nile Virus in Man

Jean K. Lim,
Andrea Lisco,
David H. McDermott,
Linda Huynh,
Jerrold M. Ward,
Bernard Johnson,
Hope Johnson,
John Pape,
Gregory A. Foster,
David Krysztof

Published: February 27, 2009
https://doi.org/10.1371/journal.ppat.1000321

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West Nile virus
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Single nucleotide polymorphisms
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Viral replication
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Homozygosity
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