A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75

• Stephen Hare,

  Affiliation Division of Medicine, Imperial College London, St. Mary's Campus, London, United Kingdom

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• Ming-Chieh Shun,

  Affiliation Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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• Saumya Shree Gupta,

  Affiliation Division of Medicine, Imperial College London, St. Mary's Campus, London, United Kingdom

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• Eugene Valkov,

  Current address: School of Molecular and Microbial Sciences, University of Queensland, Brisbane, Australia

  Affiliation Division of Medicine, Imperial College London, St. Mary's Campus, London, United Kingdom

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• Alan Engelman ,

  * E-mail: alan_engelman@dfci.harvard.edu (AE); p.cherepanov@imperial.ac.uk (PC)

  Affiliation Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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• Peter Cherepanov

  * E-mail: alan_engelman@dfci.harvard.edu (AE); p.cherepanov@imperial.ac.uk (PC)

  Affiliation Division of Medicine, Imperial College London, St. Mary's Campus, London, United Kingdom

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