A Structural Model of the Staphylococcus aureus ClfA–Fibrinogen Interaction Opens New Avenues for the Design of Anti-Staphylococcal Therapeutics

Vannakambadi K. Ganesh; Jose J. Rivera; Emanuel Smeds; Ya-Ping Ko; M. Gabriela Bowden; Elisabeth R. Wann; Shivasankarappa Gurusiddappa; J. Ross Fitzgerald; Magnus Höök

doi:10.1371/journal.ppat.1000226

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Peer-reviewed

Research Article

A Structural Model of the Staphylococcus aureus ClfA–Fibrinogen Interaction Opens New Avenues for the Design of Anti-Staphylococcal Therapeutics

Vannakambadi K. Ganesh ,

Contributed equally to this work with: Vannakambadi K. Ganesh, Jose J. Rivera

Affiliation Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A & M University Health Science Center, Houston, Texas, United States of America
⨯
Jose J. Rivera ,

Contributed equally to this work with: Vannakambadi K. Ganesh, Jose J. Rivera

Current address: Department of Infectious Diseases and Employee Health, M. D. Anderson Cancer Center, Houston, Texas, United States of America

Affiliation Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A & M University Health Science Center, Houston, Texas, United States of America
⨯
Emanuel Smeds,

Affiliation Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A & M University Health Science Center, Houston, Texas, United States of America
⨯
Ya-Ping Ko,

Affiliation Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A & M University Health Science Center, Houston, Texas, United States of America
⨯
M. Gabriela Bowden,

Affiliation Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A & M University Health Science Center, Houston, Texas, United States of America
⨯
Elisabeth R. Wann,

Affiliation Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A & M University Health Science Center, Houston, Texas, United States of America
⨯
Shivasankarappa Gurusiddappa,

Current address: Genomics and Proteomics Core Laboratory, Texas Children's Hospital, Houston, Texas, United States of America

Affiliation Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A & M University Health Science Center, Houston, Texas, United States of America
⨯
J. Ross Fitzgerald,

Affiliation Centre for Infectious Diseases, School of Biomedical Sciences, The University of Edinburgh, Edinburgh, United Kingdom
⨯
Magnus Höök

* E-mail: mhook@ibt.tamhsc.edu

Affiliation Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A & M University Health Science Center, Houston, Texas, United States of America
⨯

A Structural Model of the Staphylococcus aureus ClfA–Fibrinogen Interaction Opens New Avenues for the Design of Anti-Staphylococcal Therapeutics

Vannakambadi K. Ganesh,
Jose J. Rivera,
Emanuel Smeds,
Ya-Ping Ko,
M. Gabriela Bowden,
Elisabeth R. Wann,
Shivasankarappa Gurusiddappa,
J. Ross Fitzgerald,
Magnus Höök

Published: November 28, 2008
https://doi.org/10.1371/journal.ppat.1000226

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Crystal structure
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Integrins
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