Prevention of Cytotoxic T Cell Escape Using a Heteroclitic Subdominant Viral T Cell Determinant

Noah S. Butler; Alex Theodossis; Andrew I. Webb; Roza Nastovska; Sri Harsha Ramarathinam; Michelle A. Dunstone; Jamie Rossjohn; Anthony W. Purcell; Stanley Perlman

doi:10.1371/journal.ppat.1000186

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Open Access

Peer-reviewed

Research Article

Prevention of Cytotoxic T Cell Escape Using a Heteroclitic Subdominant Viral T Cell Determinant

Noah S. Butler ,

Contributed equally to this work with: Noah S. Butler, Alex Theodossis

Affiliations Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America, Immunology Graduate Program, University of Iowa, Iowa City, Iowa, United States of America
⨯
Alex Theodossis ,

Contributed equally to this work with: Noah S. Butler, Alex Theodossis

Affiliation The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia
⨯
Andrew I. Webb,

Affiliation Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia
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Roza Nastovska,

Affiliation Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia
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Sri Harsha Ramarathinam,

Affiliation Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia
⨯
Michelle A. Dunstone,

Affiliation The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia
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Jamie Rossjohn,

Affiliation The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia
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Anthony W. Purcell ,

* E-mail: apurcell@unimelb.edu.au (AWP); stanley-perlman@uiowa.edu (SP)

Affiliation Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia
⨯
Stanley Perlman

* E-mail: apurcell@unimelb.edu.au (AWP); stanley-perlman@uiowa.edu (SP)

Affiliation Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America
⨯

Prevention of Cytotoxic T Cell Escape Using a Heteroclitic Subdominant Viral T Cell Determinant

Noah S. Butler,
Alex Theodossis,
Andrew I. Webb,
Roza Nastovska,
Sri Harsha Ramarathinam,
Michelle A. Dunstone,
Jamie Rossjohn,
Anthony W. Purcell,
Stanley Perlman

Published: October 24, 2008
https://doi.org/10.1371/journal.ppat.1000186

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T cells
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Cytotoxic T cells
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Antigens
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