The Cysteine-Rich Interdomain Region from the Highly Variable Plasmodium falciparum Erythrocyte Membrane Protein-1 Exhibits a Conserved Structure

Michael M. Klein; Apostolos G. Gittis; Hua-Poo Su; Morris O. Makobongo; Jaime M. Moore; Sanjay Singh; Louis H. Miller; David N. Garboczi

doi:10.1371/journal.ppat.1000147

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Research Article

The Cysteine-Rich Interdomain Region from the Highly Variable Plasmodium falciparum Erythrocyte Membrane Protein-1 Exhibits a Conserved Structure

Michael M. Klein ,

Contributed equally to this work with: Michael M. Klein, Apostolos G. Gittis

Affiliation Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
⨯
Apostolos G. Gittis ,

Contributed equally to this work with: Michael M. Klein, Apostolos G. Gittis

Affiliation Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
⨯
Hua-Poo Su,

Current address: Merck & Co., Inc., West Point, Pennsylvania, United States of America

Affiliation Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
⨯
Morris O. Makobongo,

Affiliation Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
⨯
Jaime M. Moore,

Current address: University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

Affiliation Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
⨯
Sanjay Singh,

Current address: Gennova Biopharmaceuticals Limited, Pune, Maharashtra, India

Affiliation Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
⨯
Louis H. Miller,

Affiliation Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
⨯
David N. Garboczi

* E-mail: dgarboczi@niaid.nih.gov

Affiliation Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
⨯

The Cysteine-Rich Interdomain Region from the Highly Variable Plasmodium falciparum Erythrocyte Membrane Protein-1 Exhibits a Conserved Structure

Michael M. Klein,
Apostolos G. Gittis,
Hua-Poo Su,
Morris O. Makobongo,
Jaime M. Moore,
Sanjay Singh,
Louis H. Miller,
David N. Garboczi

Published: September 5, 2008
https://doi.org/10.1371/journal.ppat.1000147

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Cysteine
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Sequence alignment
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Parasitic diseases
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Disulfide bonds
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Dimers
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Malarial parasites
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Protein structure
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