Stable Cytotoxic T Cell Escape Mutation in Hepatitis C Virus Is Linked to Maintenance of Viral Fitness

Luke Uebelhoer; Jin-Hwan Han; Benoit Callendret; Guaniri Mateu; Naglaa H. Shoukry; Holly L. Hanson; Charles M. Rice; Christopher M. Walker; Arash Grakoui

doi:10.1371/journal.ppat.1000143

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Peer-reviewed

Research Article

Stable Cytotoxic T Cell Escape Mutation in Hepatitis C Virus Is Linked to Maintenance of Viral Fitness

Luke Uebelhoer,

Affiliation Department of Medicine, Division of Infectious Diseases, Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Jin-Hwan Han,

Affiliation Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University, New York, New York, United States of America
⨯
Benoit Callendret,

Affiliations The Center for Vaccines and Immunity, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, United States of America, Deparment of Pediatrics, The Ohio State University, Columbus Ohio, United States of America
⨯
Guaniri Mateu,

Affiliation Department of Medicine, Division of Infectious Diseases, Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Naglaa H. Shoukry,

Affiliation Department of Medicine, University of Montreal and Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CR-CHUM), Montréal, Québec, Canada
⨯
Holly L. Hanson,

Affiliation Department of Medicine, Division of Infectious Diseases, Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Charles M. Rice,

Affiliation Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University, New York, New York, United States of America
⨯
Christopher M. Walker,

Affiliations The Center for Vaccines and Immunity, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, United States of America, Deparment of Pediatrics, The Ohio State University, Columbus Ohio, United States of America
⨯
Arash Grakoui

* E-mail: arash.grakoui@emory.edu

Affiliation Department of Medicine, Division of Infectious Diseases, Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯

Stable Cytotoxic T Cell Escape Mutation in Hepatitis C Virus Is Linked to Maintenance of Viral Fitness

Luke Uebelhoer,
Jin-Hwan Han,
Benoit Callendret,
Guaniri Mateu,
Naglaa H. Shoukry,
Holly L. Hanson,
Charles M. Rice,
Christopher M. Walker,
Arash Grakoui

Published: September 5, 2008
https://doi.org/10.1371/journal.ppat.1000143

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T cells
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Cytotoxic T cells
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Viral replication
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Hepatitis C virus
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