The Role of B-cells and IgM Antibodies in Parasitemia, Anemia, and VSG Switching in Trypanosoma brucei–Infected Mice

Stefan Magez; Anita Schwegmann; Robert Atkinson; Filip Claes; Michael Drennan; Patrick De Baetselier; Frank Brombacher

doi:10.1371/journal.ppat.1000122

Loading metrics

Open Access

Peer-reviewed

Research Article

The Role of B-cells and IgM Antibodies in Parasitemia, Anemia, and VSG Switching in Trypanosoma brucei–Infected Mice

Stefan Magez,

Affiliations Division of Immunology, Institute for Infectious Diseases and Molecular Medicine (IIDMM), Health Science Faculty, University of Cape Town, and International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town, South Africa, Department of Molecular and Cellular Recognition, VIB, Brussels, Belgium, Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel (VUB), Brussels, Belgium
⨯
Anita Schwegmann,

Affiliation Division of Immunology, Institute for Infectious Diseases and Molecular Medicine (IIDMM), Health Science Faculty, University of Cape Town, and International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town, South Africa
⨯
Robert Atkinson,

Affiliation Division of Immunology, Institute for Infectious Diseases and Molecular Medicine (IIDMM), Health Science Faculty, University of Cape Town, and International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town, South Africa
⨯
Filip Claes,

Affiliation Laboratory of Serology, Institute for Tropical Medicine “Prins Leopold”, Antwerpen, Belgium
⨯
Michael Drennan,

Affiliations Division of Immunology, Institute for Infectious Diseases and Molecular Medicine (IIDMM), Health Science Faculty, University of Cape Town, and International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town, South Africa, Department of Molecular and Cellular Recognition, VIB, Brussels, Belgium
⨯
Patrick De Baetselier,

Affiliations Department of Molecular and Cellular Recognition, VIB, Brussels, Belgium, Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel (VUB), Brussels, Belgium
⨯
Frank Brombacher

* E-mail: fbrombac@mweb.co.za

Affiliation Division of Immunology, Institute for Infectious Diseases and Molecular Medicine (IIDMM), Health Science Faculty, University of Cape Town, and International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town, South Africa
⨯

The Role of B-cells and IgM Antibodies in Parasitemia, Anemia, and VSG Switching in Trypanosoma brucei–Infected Mice

Stefan Magez,
Anita Schwegmann,
Robert Atkinson,
Filip Claes,
Michael Drennan,
Patrick De Baetselier,
Frank Brombacher

Published: August 8, 2008
https://doi.org/10.1371/journal.ppat.1000122

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Parasitic diseases
Is the Subject Area "Parasitic diseases" applicable to this article?

Thanks for your feedback.
Trypanosoma
Is the Subject Area "Trypanosoma" applicable to this article?

Thanks for your feedback.
Antibodies
Is the Subject Area "Antibodies" applicable to this article?

Thanks for your feedback.
B cells
Is the Subject Area "B cells" applicable to this article?

Thanks for your feedback.
Parasitemia
Is the Subject Area "Parasitemia" applicable to this article?

Thanks for your feedback.
Anemia
Is the Subject Area "Anemia" applicable to this article?

Thanks for your feedback.
Trypanosomiasis
Is the Subject Area "Trypanosomiasis" applicable to this article?

Thanks for your feedback.
Trypanosoma brucei gambiense
Is the Subject Area "Trypanosoma brucei gambiense" applicable to this article?

Thanks for your feedback.