Mycolic Acid Modification by the mmaA4 Gene of M. tuberculosis Modulates IL-12 Production

Dee N. Dao; Kari Sweeney; Tsungda Hsu; Sudagar S. Gurcha; Ivan P. Nascimento; Dan Roshevsky; Gurdyal S. Besra; John Chan; Steven A. Porcelli; William R. Jacobs Jr.

doi:10.1371/journal.ppat.1000081

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Peer-reviewed

Research Article

Mycolic Acid Modification by the mmaA4 Gene of M. tuberculosis Modulates IL-12 Production

Dee N. Dao,

Affiliations Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, New York, United States of America, Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America
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Kari Sweeney,

Affiliations Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, New York, United States of America, Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America
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Tsungda Hsu,

Affiliation Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, New York, United States of America
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Sudagar S. Gurcha,

Affiliation School of Biosciences, The University of Birmingham, Edgbaston, United Kingdom
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Ivan P. Nascimento,

Affiliation Instituto Butantan, Biotecnologia Molecular IV, São Paulo, São Paulo, Brazil
⨯
Dan Roshevsky,

Affiliation Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯
Gurdyal S. Besra,

Affiliation School of Biosciences, The University of Birmingham, Edgbaston, United Kingdom
⨯
John Chan,

Affiliations Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, United States of America
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Steven A. Porcelli,

Affiliations Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯
William R. Jacobs Jr.

* E-mail: jacobsw@hhmi.org

Affiliations Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, New York, United States of America, Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯

Mycolic Acid Modification by the mmaA4 Gene of M. tuberculosis Modulates IL-12 Production

Dee N. Dao,
Kari Sweeney,
Tsungda Hsu,
Sudagar S. Gurcha,
Ivan P. Nascimento,
Dan Roshevsky,
Gurdyal S. Besra,
John Chan,
Steven A. Porcelli,
William R. Jacobs Jr.

Published: June 6, 2008
https://doi.org/10.1371/journal.ppat.1000081

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