IL-10 from CD4+CD25−Foxp3−CD127− Adaptive Regulatory T Cells Modulates Parasite Clearance and Pathology during Malaria Infection

Kevin N. Couper; Daniel G. Blount; Mark S. Wilson; Julius C. Hafalla; Yasmine Belkaid; Masahito Kamanaka; Richard A. Flavell; J. Brian de Souza; Eleanor M. Riley

doi:10.1371/journal.ppat.1000004

Loading metrics

Open Access

Peer-reviewed

Research Article

IL-10 from CD4⁺CD25⁻Foxp3⁻CD127⁻ Adaptive Regulatory T Cells Modulates Parasite Clearance and Pathology during Malaria Infection

Kevin N. Couper,

Affiliation Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Daniel G. Blount,

Current address: School of Pharmacy, University of Nottingham, University Park, Nottingham, United Kingdom

Affiliation Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Mark S. Wilson,

Affiliation Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Julius C. Hafalla,

Affiliation Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Yasmine Belkaid,

Affiliation Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Masahito Kamanaka,

Affiliation Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Richard A. Flavell,

Affiliation Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
J. Brian de Souza,

Affiliations Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom, Department of Immunology and Molecular Pathology, University College London Medical School, London, United Kingdom
⨯
Eleanor M. Riley

* E-mail: eleanor.riley@lshtm.ac.uk

Affiliation Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯

IL-10 from CD4⁺CD25⁻Foxp3⁻CD127⁻ Adaptive Regulatory T Cells Modulates Parasite Clearance and Pathology during Malaria Infection

Kevin N. Couper,
Daniel G. Blount,
Mark S. Wilson,
Julius C. Hafalla,
Yasmine Belkaid,
Masahito Kamanaka,
Richard A. Flavell,
J. Brian de Souza,
Eleanor M. Riley

Published: February 29, 2008
https://doi.org/10.1371/journal.ppat.1000004

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Parasitic diseases
Is the Subject Area "Parasitic diseases" applicable to this article?

Thanks for your feedback.
T cells
Is the Subject Area "T cells" applicable to this article?

Thanks for your feedback.
Plasmodium yoelii
Is the Subject Area "Plasmodium yoelii" applicable to this article?

Thanks for your feedback.
Regulatory T cells
Is the Subject Area "Regulatory T cells" applicable to this article?

Thanks for your feedback.
Malaria
Is the Subject Area "Malaria" applicable to this article?

Thanks for your feedback.
Malarial parasites
Is the Subject Area "Malarial parasites" applicable to this article?

Thanks for your feedback.
Immune response
Is the Subject Area "Immune response" applicable to this article?

Thanks for your feedback.
Cytopathology
Is the Subject Area "Cytopathology" applicable to this article?

Thanks for your feedback.