A Point Mutation in a Herpesvirus Polymerase Determines Neuropathogenicity

Laura B Goodman; Arianna Loregian; Gillian A Perkins; Josie Nugent; Elizabeth L Buckles; Beatrice Mercorelli; Julia H Kydd; Giorgio Palù; Ken C Smith; Nikolaus Osterrieder; Nicholas Davis-Poynter

doi:10.1371/journal.ppat.0030160

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Peer-reviewed

Research Article

A Point Mutation in a Herpesvirus Polymerase Determines Neuropathogenicity

Laura B Goodman,

Affiliation Department of Microbiology and Immunology, Cornell University, Ithaca, New York, United States of America
⨯
Arianna Loregian,

Affiliation Department of Histology, Microbiology and Medical Biotechnologies, University of Padua, Padua, Italy
⨯
Gillian A Perkins,

Affiliation Department of Clinical Sciences, Cornell University, Ithaca, New York, United States of America
⨯
Josie Nugent,

Affiliation Centre for Preventive Medicine, Animal Health Trust, Newmarket, United Kingdom
⨯
Elizabeth L Buckles,

Affiliation Department of Biomedical Sciences, Cornell University, Ithaca, New York, United States of America
⨯
Beatrice Mercorelli,

Affiliation Department of Histology, Microbiology and Medical Biotechnologies, University of Padua, Padua, Italy
⨯
Julia H Kydd,

Current address: School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, United Kingdom

Affiliation Centre for Preventive Medicine, Animal Health Trust, Newmarket, United Kingdom
⨯
Giorgio Palù,

Affiliation Department of Histology, Microbiology and Medical Biotechnologies, University of Padua, Padua, Italy
⨯
Ken C Smith,

Current address: Royal Veterinary College, Department of Pathology and Infectious Diseases, London, United Kingdom

Affiliation Centre for Preventive Medicine, Animal Health Trust, Newmarket, United Kingdom
⨯
Nikolaus Osterrieder ,

*To whom correspondence should be addressed. E-mail: no34@cornell.edu

Affiliation Department of Microbiology and Immunology, Cornell University, Ithaca, New York, United States of America
⨯
Nicholas Davis-Poynter

Current address: Herpesvirus Molecular Pathogenesis Unit, Sir Albert Sakzewski Virus Research Centre, Royal Children's Hospital Clinical Medical Virology Centre, University of Queensland, Queensland, Australia

Affiliation Centre for Preventive Medicine, Animal Health Trust, Newmarket, United Kingdom
⨯

A Point Mutation in a Herpesvirus Polymerase Determines Neuropathogenicity

Laura B Goodman,
Arianna Loregian,
Gillian A Perkins,
Josie Nugent,
Elizabeth L Buckles,
Beatrice Mercorelli,
Julia H Kydd,
Giorgio Palù,
Ken C Smith,
Nikolaus Osterrieder

Published: November 9, 2007
https://doi.org/10.1371/journal.ppat.0030160

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