Two Novel Point Mutations in Clinical Staphylococcus aureus Reduce Linezolid Susceptibility and Switch on the Stringent Response to Promote Persistent Infection

• Wei Gao,

  Affiliations Department of Microbiology, Monash University, Clayton, Victoria, Australia, Infectious Diseases Department, Austin Health, Heidelberg, Victoria, Australia, Microbiology Department, Austin Health, Heidelberg, Victoria, Australia, Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia

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• Kyra Chua,

  Affiliations Department of Microbiology, Monash University, Clayton, Victoria, Australia, Infectious Diseases Department, Austin Health, Heidelberg, Victoria, Australia, Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia

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• John K. Davies,

  Affiliation Department of Microbiology, Monash University, Clayton, Victoria, Australia

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• Hayley J. Newton,

  Affiliation Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia

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• Torsten Seemann,

  Affiliation Victorian Bioinformatics Consortium, Monash University, Clayton, Victoria, Australia

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• Paul F. Harrison,

  Affiliation Victorian Bioinformatics Consortium, Monash University, Clayton, Victoria, Australia

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• Natasha E. Holmes,

  Affiliation Infectious Diseases Department, Austin Health, Heidelberg, Victoria, Australia

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• Hyun-Woo Rhee,

  Affiliation Department of Chemistry, Seoul National University, Seoul, Korea

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• Jong-In Hong,

  Affiliation Department of Chemistry, Seoul National University, Seoul, Korea

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• Elizabeth L. Hartland,

  Affiliation Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia

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• Timothy P. Stinear ,

  ¶Joint senior author.

  Affiliations Department of Microbiology, Monash University, Clayton, Victoria, Australia, Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia

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• Benjamin P. Howden

  * E-mail: Benjamin.Howden@austin.org.au

  ¶Joint senior author.

  Affiliations Department of Microbiology, Monash University, Clayton, Victoria, Australia, Infectious Diseases Department, Austin Health, Heidelberg, Victoria, Australia, Microbiology Department, Austin Health, Heidelberg, Victoria, Australia, Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia

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