Increased Asymmetric Dimethylarginine in Severe Falciparum Malaria: Association with Impaired Nitric Oxide Bioavailability and Fatal Outcome

Tsin W. Yeo; Daniel A. Lampah; Emiliana Tjitra; Retno Gitawati; Christabelle J. Darcy; Catherine Jones; Enny Kenangalem; Yvette R. McNeil; Donald L. Granger; Bert K. Lopansri; J. Brice Weinberg; Ric N. Price; Stephen B. Duffull; David S. Celermajer; Nicholas M. Anstey

doi:10.1371/journal.ppat.1000868

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Peer-reviewed

Research Article

Increased Asymmetric Dimethylarginine in Severe Falciparum Malaria: Association with Impaired Nitric Oxide Bioavailability and Fatal Outcome

Tsin W. Yeo ,

* E-mail: tsin.yeo@menzies.edu.au

Affiliation International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia
⨯
Daniel A. Lampah,

Affiliation Menzies School of Health Research-National Institute of Health Research and Development Research Program, and District Ministry of Health, Timika, Papua, Indonesia
⨯
Emiliana Tjitra,

Affiliation National Institute of Health Research and Development, Jakarta, Indonesia
⨯
Retno Gitawati,

Affiliation National Institute of Health Research and Development, Jakarta, Indonesia
⨯
Christabelle J. Darcy,

Affiliation International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia
⨯
Catherine Jones,

Affiliation International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia
⨯
Enny Kenangalem,

Affiliation Menzies School of Health Research-National Institute of Health Research and Development Research Program, and District Ministry of Health, Timika, Papua, Indonesia
⨯
Yvette R. McNeil,

Affiliation International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia
⨯
Donald L. Granger,

Affiliation Division of Infectious Diseases, University of Utah and VA Medical Centers, Salt Lake City, Utah, United States of America
⨯
Bert K. Lopansri,

Affiliations Division of Infectious Diseases, University of Utah and VA Medical Centers, Salt Lake City, Utah, United States of America, Division of Infectious Disease, Loyola University Medical Center, Maywood, Illinois, United States of America
⨯
J. Brice Weinberg,

Affiliation Division of Hematology-Oncology, Duke and VA Medical Centers, Durham, North Carolina, United States of America
⨯
Ric N. Price,

Affiliations International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia, Centre for Vaccinology & Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, United Kingdom, Division of Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia
⨯
Stephen B. Duffull,

Affiliation School of Pharmacy, University of Otago, Dunedin, New Zealand
⨯
David S. Celermajer,

Affiliation Department of Medicine, University of Sydney and Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
⨯
Nicholas M. Anstey

Affiliations International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia, Division of Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia
⨯

Increased Asymmetric Dimethylarginine in Severe Falciparum Malaria: Association with Impaired Nitric Oxide Bioavailability and Fatal Outcome

Tsin W. Yeo,
Daniel A. Lampah,
Emiliana Tjitra,
Retno Gitawati,
Christabelle J. Darcy,
Catherine Jones,
Enny Kenangalem,
Yvette R. McNeil,
Donald L. Granger,
Bert K. Lopansri

Published: April 22, 2010
https://doi.org/10.1371/journal.ppat.1000868

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Publisher's Note: Error in figure order

Posted by PLOS_Pathogens on 11 May 2010 at 22:05 GMT

Mean values (circles) and 95%CI (bars) are displayed at each time point. Values from day 5–14 indicate mean of all values obtained during this period. X axis values show time from start of anti-malarial therapy. Numbers indicate patients examined during each time period.
http://plospathogens.org/article/info:doi/10.1371/journal.ppat.1000868#ppat-1000868-g003

The images for Figures 1 and 3 were incorrectly switched. The image that appears as Figure 1 should be Figure 3, and the image that appears as Figure 3 should be Figure 1. The figure legends appear in the correct order.

No competing interests declared.

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Increased Asymmetric Dimethylarginine in Severe Falciparum Malaria: Association with Impaired Nitric Oxide Bioavailability and Fatal Outcome

Increased Asymmetric Dimethylarginine in Severe Falciparum Malaria: Association with Impaired Nitric Oxide Bioavailability and Fatal Outcome

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Publisher's Note: Error in figure order

Posted by PLOS_Pathogens on 11 May 2010 at 22:05 GMT