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autoprotection

Posted by adevico on 12 Nov 2009 at 16:48 GMT

To our knowledge these data are the first to suggest that autocrine production of MIP-1α and MIP-1β by antigen-specific CD4+ T cells is protective against HIV-infection in vivo
http://plospathogens.org/article/info:doi/10.1371/journal.ppat.1000646#article1.body1.sec3.p2

In a certain sense this is true. However, the novelty of this observation is tempered by an earlier report from Guan et al entitled “Self-protection of individual CD4+ T cells against R5 HIV-1 infection by the synthesis of anti-viral CCR5 ligands” (PLoS One. 2008;3(10):e3481). This study from 2008 clearly showed that primary T cells are capable of antigen-specific and antigen-driven “autoprotection” from R5 HIV infection as a consequence of their secreting CCR5-binding chemokines. The results reported in the current paper are predicted by and consistent with the conclusions drawn from the earlier study.

No competing interests declared.
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