Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

Marina Tiemi Shio; Stephanie C. Eisenbarth; Myriam Savaria; Adrien F. Vinet; Marie-Josée Bellemare; Kenneth W. Harder; Fayyaz S. Sutterwala; D. Scott Bohle; Albert Descoteaux; Richard A. Flavell; Martin Olivier

doi:10.1371/journal.ppat.1000559

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Peer-reviewed

Research Article

Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

Marina Tiemi Shio,

Affiliation Department of Medicine, Microbiology and Immunology, Centre for the Study of Host Resistance, The Research Institute of the McGill University Health Centre, Montréal, Quebec, Canada
⨯
Stephanie C. Eisenbarth,

Affiliations Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Myriam Savaria,

Affiliation Department of Medicine, Microbiology and Immunology, Centre for the Study of Host Resistance, The Research Institute of the McGill University Health Centre, Montréal, Quebec, Canada
⨯
Adrien F. Vinet,

Affiliation Institut National de la Recherche Scientifique-Institut Armand-Frappier, Laval, Quebec, Canada
⨯
Marie-Josée Bellemare,

Affiliations Department of Medicine, Microbiology and Immunology, Centre for the Study of Host Resistance, The Research Institute of the McGill University Health Centre, Montréal, Quebec, Canada, Department of Chemistry, McGill University, Montréal, Quebec, Canada
⨯
Kenneth W. Harder,

Affiliation Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada
⨯
Fayyaz S. Sutterwala,

Affiliation Inflammation Program, Department of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
D. Scott Bohle,

Affiliation Department of Chemistry, McGill University, Montréal, Quebec, Canada
⨯
Albert Descoteaux,

Affiliation Institut National de la Recherche Scientifique-Institut Armand-Frappier, Laval, Quebec, Canada
⨯
Richard A. Flavell,

Affiliations Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Martin Olivier

* E-mail: martin.olivier@mcgill.ca

Affiliation Department of Medicine, Microbiology and Immunology, Centre for the Study of Host Resistance, The Research Institute of the McGill University Health Centre, Montréal, Quebec, Canada
⨯

Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

Marina Tiemi Shio,
Stephanie C. Eisenbarth,
Myriam Savaria,
Adrien F. Vinet,
Marie-Josée Bellemare,
Kenneth W. Harder,
Fayyaz S. Sutterwala,
D. Scott Bohle,
Albert Descoteaux,
Richard A. Flavell

Published: August 21, 2009
https://doi.org/10.1371/journal.ppat.1000559

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Publisher's Note: Correction to Figure 2

Posted by PLOS_Pathogens on 09 Dec 2009 at 20:44 GMT

Figure 2
IL-1β production and neutrophil recruitment induced by hemozoin requires NLRP3, ASC and IL-1β but not NLRC4.
http://plospathogens.org/article/info:doi/10.1371/journal.ppat.1000559#ppat-1000559-g002

The Y axis in panels B, C, and D of Figure 2 is incorrect, the correct axes should read "Neutrophils (x10^5)".

The corrected figure can be found here:
http://www.plospathogens.org/corrections/ppat.1000559.g002.cn.tif

No competing interests declared.

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Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

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Publisher's Note: Correction to Figure 2

Posted by PLOS_Pathogens on 09 Dec 2009 at 20:44 GMT