About the Authors

Taylor L. Corridon

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Program in Brain Health, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Jill O’Moore

Roles Investigation, Writing – review & editing

Affiliation Weissman Hood Institute, Great Falls, Montana, United States of America

Alyssa Seerley

Roles Investigation, Writing – review & editing

Affiliation Weissman Hood Institute, Great Falls, Montana, United States of America

Daniel A. Sprague

Roles Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Program in Brain Health, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Yuan Lian

Roles Formal analysis, Writing – review & editing

Affiliation Program in Brain Health, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Vanessa Laversenne

Roles Investigation, Writing – review & editing

Affiliation Program in Brain Health, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Briana Noble

Roles Investigation, Writing – review & editing

Affiliation Ionis Pharmaceuticals, Carlsbad, California, United States of America

Nikita G. Kamath

Roles Investigation, Writing – review & editing

Affiliation Program in Brain Health, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Fiona E. Serack

Roles Investigation, Writing – review & editing

Affiliation Program in Brain Health, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Abdul Basit Shaikh

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Charles River Laboratories, Worcester, Massachusetts, United States of America

Brian Erickson

Roles Conceptualization, Investigation, Writing – review & editing

Affiliation IQ Proteomics, Framingham, Massachusetts, United States of America

Craig Braun

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation IQ Proteomics, Framingham, Massachusetts, United States of America

Kendrick DeSouza-Lenz

Roles Investigation, Writing – review & editing

Affiliation Comparative Medicine, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Michael Howard

Roles Investigation, Writing – review & editing

Affiliation Comparative Medicine, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Nathan Chan

Roles Investigation, Writing – review & editing

Affiliation Comparative Medicine, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Walker S. Jackson

Roles Conceptualization, Writing – review & editing

Affiliation Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden

Andrew G. Reidenbach

Roles Conceptualization, Investigation, Writing – review & editing

Current address: Magnet Biomedicine, Boston, Massachusetts, United States of America

Affiliation Program in Brain Health, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Deborah E. Cabin

Roles Investigation, Writing – review & editing

Affiliation Weissman Hood Institute, Great Falls, Montana, United States of America

Sonia M. Vallabh

Roles Conceptualization, Writing – review & editing

Affiliations Program in Brain Health, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, McCance Center for Brain Health and Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Neurology, Harvard Medical School, Boston, Massachusetts, United States of America, Prion Alliance, Cambridge, Massachusetts, United States of America

Andrea Grindeland Panter

Roles Conceptualization, Writing – review & editing

Affiliation Weissman Hood Institute, Great Falls, Montana, United States of America

Nina Oberbeck

Roles Conceptualization, Formal analysis, Writing – review & editing

Affiliation Gate Bio, Brisbane, California, United States of America

Hien T. Zhao

Roles Conceptualization, Formal analysis, Writing – review & editing

Affiliation Ionis Pharmaceuticals, Carlsbad, California, United States of America

Eric Vallabh Minikel

Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing

eminikel@broadinstitute.org

Affiliations Program in Brain Health, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, McCance Center for Brain Health and Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Neurology, Harvard Medical School, Boston, Massachusetts, United States of America, Prion Alliance, Cambridge, Massachusetts, United States of America

Competing Interests

We have read the journal’s policy and the authors of this manuscript have the following competing interests. BE and CB are employees of IQ Proteomics. ABS is an employee of Charles River Laboratories. NO is an employee and shareholder of Gate Bio. HTZ and BN are employees and shareholders of Ionis Pharmaceuticals. EVM has received speaking fees from Abbvie, Eli Lilly, Novartis, Vertex, and Voyager; consulting fees from Alnylam, Arrowhead, Deerfield, and Regeneron; and research support from Cenos, Eli Lilly, Gate Bio, Ionis, Regeneron, and Sangamo Therapeutics. SMV acknowledges speaking fees from Abbvie, Biogen, Eli Lilly, Illumina, Ultragenyx, and Voyager; consulting fees from Alnylam, Invitae, and Regeneron; research support from Cenos, Eli Lilly, Gate Bio, Ionis, Regeneron, and Sangamo Therapeutics.