Experimental evolution of fungal pathogens as a tool to unravel host adaptation and virulence

Paul Mathias Jansen; Bernhard Hube; Sascha Brunke

doi:10.1371/journal.ppat.1014149

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Experimental evolution of fungal pathogens as a tool to unravel host adaptation and virulence

Paul Mathias Jansen,

Affiliation Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany
⨯
Bernhard Hube ,

* E-mail: bernhard.hube@leibniz-hki.de (BH); sascha.brunke@leibniz-hki.de (SB)

Affiliations Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany, Institute of Microbiology, Friedrich Schiller University, Jena, Germany, Cluster of Excellence Balance of the Microverse, Friedrich Schiller University Jena, Jena, Germany

https://orcid.org/0000-0002-6028-0425

⨯
Sascha Brunke

* E-mail: bernhard.hube@leibniz-hki.de (BH); sascha.brunke@leibniz-hki.de (SB)

Affiliation Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany
⨯

Experimental evolution of fungal pathogens as a tool to unravel host adaptation and virulence

Paul Mathias Jansen,
Bernhard Hube,
Sascha Brunke

Published: April 24, 2026
https://doi.org/10.1371/journal.ppat.1014149

About the Authors

Paul Mathias Jansen

Affiliation Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany

Bernhard Hube

* E-mail: bernhard.hube@leibniz-hki.de (BH); sascha.brunke@leibniz-hki.de (SB)

Affiliations Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany, Institute of Microbiology, Friedrich Schiller University, Jena, Germany, Cluster of Excellence Balance of the Microverse, Friedrich Schiller University Jena, Jena, Germany

https://orcid.org/0000-0002-6028-0425

Sascha Brunke

* E-mail: bernhard.hube@leibniz-hki.de (BH); sascha.brunke@leibniz-hki.de (SB)

Affiliation Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany

Competing Interests

The authors have declared that no competing interests exist.

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Fungal evolution
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Evolutionary immunology
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Fungal pathogens
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Microbial evolution
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Mouse models
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Evolutionary adaptation
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Macrophages
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Evolutionary genetics
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