About the Authors

Ruxiao Xing

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

‡ Co-first authors.

Affiliation Department of Genetic and Cellular Medicine, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America

Mengyao Xu

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

‡ Co-first authors.

Affiliation Department of Genetic and Cellular Medicine, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America

Darcy Reil

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation Department of Genetic and Cellular Medicine, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America

April Destefano

Roles Investigation, Methodology

Affiliation Department of Genetic and Cellular Medicine, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America

Mengtian Cui

Roles Methodology, Resources, Software

Affiliation Department of Genetic and Cellular Medicine, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America

Nan Liu

Roles Investigation, Methodology

Affiliation Department of Genetic and Cellular Medicine, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America

Jialing Liang

Roles Investigation, Methodology

Affiliation Department of Genetic and Cellular Medicine, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America

Guangchao Xu

Roles Resources

Affiliation Department of Genetic and Cellular Medicine, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America

Li Luo

Roles Resources

Affiliation Department of Genetic and Cellular Medicine, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America

Meiyu Xu

Roles Investigation, Methodology

Affiliation Department of Genetic and Cellular Medicine, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America

Fang Zhang

Roles Investigation, Methodology, Resources

Affiliation Department of Genetic and Cellular Medicine, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America

Phillip W.L. Tai

Roles Methodology, Resources, Software

Affiliation Department of Genetic and Cellular Medicine, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America

Yuquan Wei

Roles Resources

Affiliation State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China

Alisha M. Gruntman

Roles Data curation, Formal analysis, Investigation, Methodology, Resources

Affiliation Department of Genetic and Cellular Medicine, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America

Terence R. Flotte

Roles Funding acquisition, Resources

Affiliation Department of Genetic and Cellular Medicine, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America

Guangping Gao

Roles Funding acquisition, Supervision

Dan.Wang@umassmed.edu (DW); Guangping.Gao@umassmed.edu (GG)

Affiliations Department of Genetic and Cellular Medicine, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America, Department of Microbiology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America

Dan Wang

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Supervision, Visualization, Writing – review & editing

Dan.Wang@umassmed.edu (DW); Guangping.Gao@umassmed.edu (GG)

Affiliations Department of Genetic and Cellular Medicine, Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America, RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America

Competing Interests

I have read the journal’s policy and the authors of this manuscript have the following competing interests: G.X., L.L., P.W.L.T., Y.W., G.G. are inventors of a patent application regarding the AAV8 variants described in this study (US20230374545A1). G.G. is a scientific co-founder of Voyager Therapeutics, Adrenas Therapeutics and Aspa Therapeutics and holds equity in these companies.