Schistosoma japonicum leishmanolysin SjLLPi1 facilitates the invasion of cercariae into the host skin

Fanyan Chen; Bingkuan Zhu; Yu Fang; Zilüe Li; Zhigang Lei; Zechao Xue; Tao Shen; Sha Zhou; Xiaojun Chen; Lei Xu; Yalin Li; Jifeng Zhu; Wei Hu; Chuan Su

doi:10.1371/journal.ppat.1013446

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Open Access

Peer-reviewed

Research Article

Schistosoma japonicum leishmanolysin SjLLPi1 facilitates the invasion of cercariae into the host skin

Fanyan Chen ,

Contributed equally to this work with: Fanyan Chen, Bingkuan Zhu, Yu Fang, Zilüe Li, Zhigang Lei

Roles Data curation, Investigation, Methodology, Software

Affiliations Key Laboratory for Pathogen Infection and Control of Jiangsu Province, Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, Jiangsu, China, Department of Laboratory Medicine, The Eighth Hospital of Wuhan, Wuhan, Hubei, China
⨯
Bingkuan Zhu ,

Contributed equally to this work with: Fanyan Chen, Bingkuan Zhu, Yu Fang, Zilüe Li, Zhigang Lei

Roles Data curation, Investigation, Methodology, Software

Affiliation State Key Laboratory of Genetic Engineering, Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China
⨯
Yu Fang ,

Contributed equally to this work with: Fanyan Chen, Bingkuan Zhu, Yu Fang, Zilüe Li, Zhigang Lei

Roles Data curation, Investigation, Methodology

Affiliation Key Laboratory for Pathogen Infection and Control of Jiangsu Province, Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Zilüe Li ,

Contributed equally to this work with: Fanyan Chen, Bingkuan Zhu, Yu Fang, Zilüe Li, Zhigang Lei

Roles Investigation, Writing – original draft

Affiliation Key Laboratory for Pathogen Infection and Control of Jiangsu Province, Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Zhigang Lei ,

Contributed equally to this work with: Fanyan Chen, Bingkuan Zhu, Yu Fang, Zilüe Li, Zhigang Lei

Roles Investigation, Writing – original draft

Affiliation Key Laboratory for Pathogen Infection and Control of Jiangsu Province, Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Zechao Xue,

Roles Investigation

Affiliation Key Laboratory for Pathogen Infection and Control of Jiangsu Province, Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Tao Shen,

Roles Investigation

Affiliation Key Laboratory for Pathogen Infection and Control of Jiangsu Province, Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Sha Zhou,

Roles Investigation

Affiliation Key Laboratory for Pathogen Infection and Control of Jiangsu Province, Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Xiaojun Chen,

Roles Investigation

Affiliation Key Laboratory for Pathogen Infection and Control of Jiangsu Province, Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Lei Xu,

Roles Investigation

Affiliation Key Laboratory for Pathogen Infection and Control of Jiangsu Province, Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Yalin Li,

Roles Investigation

Affiliation Key Laboratory for Pathogen Infection and Control of Jiangsu Province, Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Jifeng Zhu ,

Roles Conceptualization, Data curation, Methodology, Project administration, Software, Writing – original draft, Writing – review & editing

* E-mail: chuansu@njmu.edu.cn (CS); huw@fudan.edu.cn (WH); zhujifengfinn@njmu.edu.cn (JZ)

Affiliation Key Laboratory for Pathogen Infection and Control of Jiangsu Province, Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Wei Hu ,

Roles Conceptualization, Writing – review & editing

* E-mail: chuansu@njmu.edu.cn (CS); huw@fudan.edu.cn (WH); zhujifengfinn@njmu.edu.cn (JZ)

Affiliation State Key Laboratory of Genetic Engineering, Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China
⨯
Chuan Su

Roles Conceptualization, Funding acquisition, Project administration, Writing – review & editing

* E-mail: chuansu@njmu.edu.cn (CS); huw@fudan.edu.cn (WH); zhujifengfinn@njmu.edu.cn (JZ)

Affiliation Key Laboratory for Pathogen Infection and Control of Jiangsu Province, Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, Jiangsu, China

https://orcid.org/0000-0002-8271-2428

⨯

Schistosoma japonicum leishmanolysin SjLLPi1 facilitates the invasion of cercariae into the host skin

Fanyan Chen,
Bingkuan Zhu,
Yu Fang,
Zilüe Li,
Zhigang Lei,
Zechao Xue,
Tao Shen,
Sha Zhou,
Xiaojun Chen,
Lei Xu

Published: August 26, 2025
https://doi.org/10.1371/journal.ppat.1013446

About the Authors

Fanyan Chen

Contributed equally to this work with: Fanyan Chen, Bingkuan Zhu, Yu Fang, Zilüe Li, Zhigang Lei

Roles Data curation, Investigation, Methodology, Software

Affiliations Key Laboratory for Pathogen Infection and Control of Jiangsu Province, Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, Jiangsu, China, Department of Laboratory Medicine, The Eighth Hospital of Wuhan, Wuhan, Hubei, China

Bingkuan Zhu

Contributed equally to this work with: Fanyan Chen, Bingkuan Zhu, Yu Fang, Zilüe Li, Zhigang Lei

Roles Data curation, Investigation, Methodology, Software

Affiliation State Key Laboratory of Genetic Engineering, Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China

Yu Fang

Contributed equally to this work with: Fanyan Chen, Bingkuan Zhu, Yu Fang, Zilüe Li, Zhigang Lei

Roles Data curation, Investigation, Methodology

Affiliation Key Laboratory for Pathogen Infection and Control of Jiangsu Province, Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, Jiangsu, China

Zilüe Li

Contributed equally to this work with: Fanyan Chen, Bingkuan Zhu, Yu Fang, Zilüe Li, Zhigang Lei

Roles Investigation, Writing – original draft

Zhigang Lei

Contributed equally to this work with: Fanyan Chen, Bingkuan Zhu, Yu Fang, Zilüe Li, Zhigang Lei

Roles Investigation, Writing – original draft

Zechao Xue

Roles Investigation

Tao Shen

Roles Investigation

Sha Zhou

Roles Investigation

Xiaojun Chen

Roles Investigation

Lei Xu

Roles Investigation

Yalin Li

Roles Investigation

Jifeng Zhu

Roles Conceptualization, Data curation, Methodology, Project administration, Software, Writing – original draft, Writing – review & editing

* E-mail: chuansu@njmu.edu.cn (CS); huw@fudan.edu.cn (WH); zhujifengfinn@njmu.edu.cn (JZ)

Wei Hu

Roles Conceptualization, Writing – review & editing

* E-mail: chuansu@njmu.edu.cn (CS); huw@fudan.edu.cn (WH); zhujifengfinn@njmu.edu.cn (JZ)

Affiliation State Key Laboratory of Genetic Engineering, Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China

Chuan Su

Roles Conceptualization, Funding acquisition, Project administration, Writing – review & editing

* E-mail: chuansu@njmu.edu.cn (CS); huw@fudan.edu.cn (WH); zhujifengfinn@njmu.edu.cn (JZ)

https://orcid.org/0000-0002-8271-2428

Competing Interests

The authors have declared that no competing interests exist.

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Parasitic diseases
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Schistosoma japonicum
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Antibody therapy
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Monoclonal antibodies
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Proteases
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Skin infections
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Macrophages
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Schistosoma
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