About the Authors

Florencia Sabbione

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Visualization, Writing – review & editing

Affiliation Laboratorio de inmunidad innata, Instituto de Medicina Experimental (IMEX)—CONICET, Academia Nacional de Medicina, Buenos Aires, Argentina

Irene Angelica Keitelman

Contributed equally to this work with: Irene Angelica Keitelman, Carolina Maiumi Shiromizu

Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

Affiliation Laboratorio de inmunidad innata, Instituto de Medicina Experimental (IMEX)—CONICET, Academia Nacional de Medicina, Buenos Aires, Argentina

Carolina Maiumi Shiromizu

Contributed equally to this work with: Irene Angelica Keitelman, Carolina Maiumi Shiromizu

Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

Affiliation Laboratorio de inmunidad innata, Instituto de Medicina Experimental (IMEX)—CONICET, Academia Nacional de Medicina, Buenos Aires, Argentina

Alexia Vereertbrugghen

Roles Investigation

Affiliation Laboratorio de inmunidad innata, Instituto de Medicina Experimental (IMEX)—CONICET, Academia Nacional de Medicina, Buenos Aires, Argentina

Douglas Vera Aguilar

Roles Investigation

Affiliation Laboratorio de inmunidad innata, Instituto de Medicina Experimental (IMEX)—CONICET, Academia Nacional de Medicina, Buenos Aires, Argentina

Paolo Nahuel Rubatto Birri

Roles Investigation

Affiliation Laboratorio de inmunidad innata, Instituto de Medicina Experimental (IMEX)—CONICET, Academia Nacional de Medicina, Buenos Aires, Argentina

Manuela Pizzano

Roles Investigation

Affiliation Laboratorio de inmunidad innata, Instituto de Medicina Experimental (IMEX)—CONICET, Academia Nacional de Medicina, Buenos Aires, Argentina

María Victoria Ramos

Roles Investigation, Resources

Affiliation Laboratorio de patogénesis e inmunología de procesos infecciosos. Instituto de Medicina Experimental (IMEX)—CONICET, Academia Nacional de Medicina, Buenos Aires, Argentina

Federico Fuentes

Roles Investigation

Affiliation Laboratorio de microscopía, Instituto de Medicina Experimental (IMEX)—CONICET, Academia Nacional de Medicina, Buenos Aires, Argentina

Lucas Saposnik

Roles Investigation, Resources

Affiliations Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín (UNSAM)–Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de San Martín. San Martín, Buenos Aires, Argentina, Escuela de Bio y Nanotecnologías (EByN), Universidad Nacional de San Martín. San Martín, Buenos Aires, Argentina

Agostina Cernutto

Roles Investigation

Affiliation Laboratorio de inmunidad innata, Instituto de Medicina Experimental (IMEX)—CONICET, Academia Nacional de Medicina, Buenos Aires, Argentina

Juliana Cassataro

Roles Resources, Writing – review & editing

Affiliations Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín (UNSAM)–Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de San Martín. San Martín, Buenos Aires, Argentina, Escuela de Bio y Nanotecnologías (EByN), Universidad Nacional de San Martín. San Martín, Buenos Aires, Argentina

Carolina Cristina Jancic

Roles Investigation

Affiliations Laboratorio de inmunidad innata, Instituto de Medicina Experimental (IMEX)—CONICET, Academia Nacional de Medicina, Buenos Aires, Argentina, Departamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina

Jeremías Gaston Galletti

Roles Conceptualization, Funding acquisition, Project administration, Writing – review & editing

Affiliation Laboratorio de inmunidad innata, Instituto de Medicina Experimental (IMEX)—CONICET, Academia Nacional de Medicina, Buenos Aires, Argentina

Marina Sandra Palermo

Roles Conceptualization, Project administration, Resources, Writing – review & editing

Affiliation Laboratorio de patogénesis e inmunología de procesos infecciosos. Instituto de Medicina Experimental (IMEX)—CONICET, Academia Nacional de Medicina, Buenos Aires, Argentina

Analía Silvina Trevani

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

analiatrevani@gmail.com

Affiliations Laboratorio de inmunidad innata, Instituto de Medicina Experimental (IMEX)—CONICET, Academia Nacional de Medicina, Buenos Aires, Argentina, Departamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina

Competing Interests

JC is inventor of a patent related to Ecotin. The patent “Immunomodulating and immunostimulating polypeptides for drug-delivery” was filled on February 8, 2019 by the authors’ National Research Council (CONICET) and the University of San Martin (UNSAM) in the United States patent and trademark Office (US2021009371), the European patent office (PCT/IB2019/051026, EP3749364), the China National intellectual property administration (CN111936166), and the National Institute of Intellectual Property from Argentina (AR114683). The filing of the patent did not have any role in experimental design, data collection and analysis, decision to publish, or preparation of this manuscript. The authors have no financial conflicts of interest.