About the Authors

Yuqi Zhou

Roles Conceptualization, Investigation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Microbiology and Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Julie Jadlowsky

Roles Conceptualization, Investigation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Microbiology and Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Caitlin Baiduc

Roles Investigation, Writing – review & editing

Affiliation Department of Microbiology and Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Alex W. Klattenhoff

Roles Investigation, Methodology, Writing – review & editing

Affiliation Department of Microbiology and Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Zhilin Chen

Roles Investigation

Affiliation Department of Microbiology and Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Alan D. Bennett

Roles Investigation, Writing – review & editing

Affiliation Adaptimmune Ltd, Abingdon, United Kingdom

Nicholas J. Pumphrey

Roles Investigation

Affiliation Adaptimmune Ltd, Abingdon, United Kingdom

Bent K. Jakobsen

Roles Conceptualization, Funding acquisition, Supervision

Affiliations Adaptimmune Ltd, Abingdon, United Kingdom, Immunocore Ltd., Abingdon, United Kingdom

James L. Riley

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

rileyj@upenn.edu

Affiliation Department of Microbiology and Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Competing Interests

I have read the journal’s policy and the authors of this manuscript have the following competing interests: AB, NLP, and BKJ were employees of Adaptimmune when these studies were performed. Adaptimmune hold patents on TCRs described in this manuscript. JLR is an inventor of patents related to the HIV CAR therapy, which is the subject of this paper, as well as other CAR therapy products, and may be eligible to receive a select portion of royalties paid from Kite to the University of Pennsylvania. JLR is a scientific co-founder and holds equity in BlueWhale Bio.