About the Authors

Elisabet Bjanes

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Current address: Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America

Affiliations Cell and Molecular Biology Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America

Reyna Garcia Sillas

Roles Investigation

Affiliation Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America

Rina Matsuda

Roles Formal analysis, Investigation

Affiliations Cell and Molecular Biology Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America

Benjamin Demarco

Roles Investigation

Affiliation Department of Biochemistry, University of Lausanne, Epalinges, Vaud, Switzerland

Timothée Fettrelet

Roles Investigation

Affiliation Department of Biochemistry, University of Lausanne, Epalinges, Vaud, Switzerland

Alexandra A. DeLaney

Roles Investigation

Affiliations Cell and Molecular Biology Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America

Opher S. Kornfeld

Roles Investigation

Affiliation Department of Physiological Chemistry, Genentech Inc., South San Francisco, California, United States of America

Bettina L. Lee

Roles Investigation

Affiliation Department of Physiological Chemistry, Genentech Inc., South San Francisco, California, United States of America

Eric M. Rodríguez López

Roles Investigation

Affiliations Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America, Immunology Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

Daniel Grubaugh

Roles Investigation

Affiliation Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America

Meghan A. Wynosky-Dolfi

Roles Investigation

Current address: Immunology Research Unit, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America

Affiliation Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America

Naomi H. Philip

Roles Investigation

Current address: Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America

Affiliations Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America, Immunology Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

Elise Krespan

Roles Investigation, Resources

Affiliations Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America, Center for Host Microbial Interactions, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America

Dorothy Tovar

Roles Investigation

Current address: Department of Microbiology & Immunology, Stanford University School of Medicine, Palo Alto California, United States of America

Affiliation Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America

Leonel Joannas

Roles Resources, Supervision

Affiliations Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America, CRISPR/Cas9 Mouse Targeting Core, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America

Daniel P. Beiting

Roles Resources

Affiliations Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America, Center for Host Microbial Interactions, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America, Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

Jorge Henao-Mejia

Roles Funding acquisition, Resources, Supervision

Affiliations Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Division of Protective Immunity, Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Brian C. Schaefer

Roles Funding acquisition, Resources, Writing – review & editing

Affiliation Department of Microbiology and Immunology, Uniformed Services University, Bethesda, Maryland, United States of America

Kaiwen W. Chen

Roles Supervision, Writing – review & editing

Current address: Immunology Programme and Department of Microbiology & Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

Affiliation Department of Biochemistry, University of Lausanne, Epalinges, Vaud, Switzerland

Petr Broz

Roles Resources, Supervision

Affiliation Department of Biochemistry, University of Lausanne, Epalinges, Vaud, Switzerland

Igor E. Brodsky

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

ibrodsky@vet.upenn.edu

Affiliations Cell and Molecular Biology Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America, Immunology Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America, Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

Competing Interests

I have read the journal’s policy and the authors of this manuscript have the following competing interests: Opher S. Kornfeld and Bettina L. Lee are employees of Genentech.